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Medicinal composition containing calcium and iron elements

A composition and iron technology, applied in the directions of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of low absorption and utilization rate of calcium and iron, gastrointestinal reactions, low solubility, etc. The effect of reducing the occurrence of rickets, preventing pregnancy poisoning, and high absorption rate in the human body

Inactive Publication Date: 2006-09-06
北京海王中新药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many types of calcium supplements available in the market, but they generally have three defects: low solubility, low calcium content and low absorption
Many iron supplements have side effects such as gastrointestinal reactions and constipation
And when calcium supplement and iron supplement are taken orally at the same time, there is another technical problem: in terms of chemical structure, calcium and low-priced iron (ferrous iron) are all divalent cations, which contradict and antagonize each other in the process of absorption and metabolism in the body. , so that the absorption and utilization of calcium and iron are very low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 prepares calcium-iron complex agent tablet

[0019] Take by weight "Psoraleae: Calcium Citrate Malate Coordination Compound: Iron Glycinate Coordination Compound=1400:40:1" ratio to take three raw materials, pulverize Psoraleae, cross a 120 mesh sieve, and The calcium citrate malate coordination compound and the iron glycinate coordination compound are mixed evenly, and conventional auxiliary materials such as excipients are added. Rolled into flakes. The daily oral dose is equivalent to 14g of crude drug psoralen, 300mg of calcium citrate malate complex, and 10mg of iron glycinate complex.

Embodiment 2

[0020] Embodiment 2 prepares calcium-iron compound agent capsule

[0021] Weigh the three raw materials according to the ratio of "Psoralen: Calcium Citrate Malate Coordination Compound: Iron Glycinate Coordination Compound = 1500:36:1", and decoct the psoralen 3 times, 2 hours each time , take the decoction, concentrate, dry, and pulverize to obtain a fine powder, mix it with calcium citrate malate complex and iron glycinate complex evenly, and put it into capsules to obtain the finished product. The daily oral dose is equivalent to 15g of crude drug psoralen, 360mg of calcium citrate malate complex, and 10mg of iron glycinate complex.

Embodiment 3

[0022] Embodiment 3 prepares calcium-iron compound nutritional oral liquid (syrup)

[0023] Recipe: psoralen 1400g, calcium citrate malate complex 30g

[0024] Iron Glycine Coordination Compound 1g Amino Acid 5g Honey 100g

[0025] 250g of granulated sugar, 2g of citric acid, and an appropriate amount of essence.

[0026] Preparation:

[0027] 1. Boil psoralen with water for 3 times, 2 hours for the first time, 1.5 hours for the second time, and 1 hour for the third time. Combine the decoctions, filter, concentrate the filtrate to about 1 liter, let it cool, add 1.5 liters of ethanol, stir evenly, let it stand for 24 hours, filter, concentrate the filtrate under reduced pressure to an extract, dilute with an appropriate amount of water, and filter. spare.

[0028] 2. Dissolve granulated sugar in water, filter to a concentration of 65%, sterilize, and cool to below 30°C. Add honey, amino acid, citric acid, psoralen extract, calcium citrate malate complex, iron glycinate co...

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PUM

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Abstract

A medical composition containing Ca and Fe elements without antagonism is prepared from malaytea scurfpea fruit (1200-1600 portions), coordination compound of calcium malate citrate (10-200), and coordination compound of iron glycinate (1).

Description

(1) Technical field [0001] The invention belongs to the pharmaceutical composition containing calcium element and iron element at the same time, which is used for the treatment and prevention of diseases caused by the deficiency of calcium element and / or iron element. (2) Background technology [0002] Calcium and iron have important physiological and biochemical functions for the human body, and are important factors for the human body to maintain health. At the same time, calcium and iron play an important role in the occurrence, development and outcome of various human diseases. Unfortunately, calcium and iron deficiencies are common in natural populations, and often deficiencies of both elements occur simultaneously. Calcium and iron deficiency is more common in certain special populations (such as the elderly, children, pregnant women, and lactating women), leading to the occurrence of various diseases. From a nutritional point of view, adequate supply of calcium and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/194A61K31/195A61K36/487A61P3/02
Inventor 马永华
Owner 北京海王中新药业股份有限公司
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