Gossypol acetate raw material medicinal preparation for treating gynecopathy

A technology for gossypol acetate and gynecological diseases, which is applied in the field of gossypol acetate raw material medicine preparations, and can solve the problems of heavy burden on patients, high cost, and large side effects

Active Publication Date: 2006-03-22
SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no production of gossypol acetate to treat gynecological diseases. Gynecological diseases seriously plague the majority of women, especially functional uterine bleeding, uterine fibroids, menorrhagia, endometriosis, etc. According to reports at home and abroad, Although medicines for treating these diseases are constantly on the market, the cure rate of gynecological diseases still has a certain limit. Some medicines with good curative effect have high cost, large side effects, and heavy burden on patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Get gossypol acetate 100g, potassium chloride 2000g, 80g vitamin B1, 80g vitamin B6, starch 500g, dextrin 300g and make 10000 tablets altogether according to the above-mentioned method, cure mainly: functional uterine bleeding, hysteromyoma, menstruation excess, endometriosis.

Embodiment 2

[0030] Example 2: Take gossypol acetate 15%, Astragalus 20%, Codonopsis 5%, Motherwort 20%, Angelica 10%, Eclipta 6%, oyster 14%, Curcuma 10% by weight, and make 10,000 capsules in total . Indications: functional uterine bleeding, uterine tumors, breast hyperplasia, menorrhagia, endometriosis.

Embodiment 3

[0033] Example 3 Synthesize 10,000 tablets by weight ratio with gossypol acetate 76% adjuvant starch 24% by conventional method.

[0034] Gossypol was used to treat 148 cases of menorrhagia, 88 cases of uterine fibroids, 26 cases of endometriosis and adenomyosis, a total of 262 cases. The treatment plan was to take gossypol acetate (20 mg) orally once a day. Change the maintenance dose twice a week, 20mg each time, and stop the drug after 3 months. Results The total effective rate was 84.7%. For patients with uterine fibroids, the effective rate was 93.2% based on the reduction of menstrual flow, and the effective rate was 36.4% based on the reduction of uterine fibroids. The treatment of endometriosis and adenomyosis was based on the improvement of dysmenorrhea. The effective rate was 88.5%, and the effective rate was 84.6% based on the improvement of sacroiliac ligament tenderness. The shortest course of treatment for endometriosis and adenomyosis, the pain can be relieved ...

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PUM

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Abstract

The present invention relates to medicine preparation for treating women's diseases, and is especially medicine preparation containing gossypol acetate as main component for treating women's diseases. The medicine preparation contains gossypol acetate 3-5 wt%, potassium chloride 56-64 wt%, vitamin B1 2-3 wt%, vitamin B6 2-3 wt%, starch 12-15 wt% and dextrin 10-18 wt%. The medicine preparation has high curative effect, less side effect and low cost.

Description

technical field [0001] The invention relates to a raw material drug preparation for treating gynecological diseases, in particular to a raw material drug preparation of gossypol acetate for treating gynecological diseases. Background technique [0002] Since the 1970s, gossypol has been used as a special research project for male birth control drugs in my country. Through a large number of researches and experiments, gossypol was first tested clinically in Jiangsu in February 1972, and a significant effect on male anti-fertility was obtained. Since then The national gossypol clinical collaboration started. A total of 8,806 cases were tried. Through data collection, the anti-fertility effect of the prepared gossypol was very significant. Among them, 5,208 cases took gossypol acetate, and the effective rate reached 98.62%. But there is no production of gossypol acetate to treat gynecological diseases. Gynecological diseases seriously plague the majority of women, especially fu...

Claims

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Application Information

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IPC IPC(8): A61K31/222A61K9/20A61K9/48A61K9/08A61P15/00
Inventor 谢晓林
Owner SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD
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