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Notiginseng total saponin liposome and its preparation

A technology of total saponins and total saponins of Panax notoginseng, which is applied in the directions of liposome delivery, pill delivery, aerosol delivery, etc., can solve the problems affecting the stability of liposomes of total notoginseng saponins, phospholipids are prone to hydrolysis and oxidation reactions , thermodynamic instability, etc.

Inactive Publication Date: 2005-07-27
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, because notoginseng total saponin liposome belongs to colloid dispersion system, belongs to thermodynamically unstable system, its membrane material component phospholipid is prone to hydrolysis and oxidation reaction, and the temperature of external environment, pH value easily cause the change of liposome structure, thereby Cause the leakage of drugs in liposomes and affect the stability of liposomes with total saponins of notoginseng during storage
This is a technical problem that has not been well solved for a long time

Method used

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  • Notiginseng total saponin liposome and its preparation
  • Notiginseng total saponin liposome and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0207] Dissolve 30 g of Panax notoginseng saponins in pH7.2 phosphate buffer, add 120 g of soybean lecithin, 50 g of cholesterol, and 10 g of dicetyl phosphate in 200 ml of chloroform under nitrogen flow, and evaporate under reduced pressure to remove chloroform. The raffinate is ultrasonically dispersed to disperse the liposomes, and diluted with an appropriate amount of buffer solution to obtain a liposome solution of Panax notoginseng saponins.

Embodiment 2

[0209] Dissolve 40g of lecithin and 50g of cholesterol in ether, add a solution containing 8g of Panax notoginseng saponins prepared with 4mmol / L phosphate buffer solution, treat with ultrasonic waves for 2 minutes, and immediately evaporate under reduced pressure on a water bath until a gel appears vortex to invert the phase of the gel, then continue to evaporate to remove ether, ultracentrifuge for 30 minutes, separate and remove the unincluded Panax notoginseng saponins, wash the precipitate twice with water, centrifuge to obtain the precipitate, and use 10mmol / L phosphoric acid The saline buffer solution is diluted to obtain the total saponin liposome solution of notoginseng.

Embodiment 3

[0211] Take 80g of egg yolk lecithin, 20g of cholesterol, and 10g of octadecylamine and dissolve them in absolute ethanol, etc., and remove the ethanol under reduced pressure to form a film. Take off, sonicate for 20 minutes, and centrifuge to remove unencapsulated drug to obtain a liposome suspension.

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Abstract

The present invention discloses total notoginseng saponin liposome and its preparation. The total notoginseng saponin liposome contains total notoginseng saponin 5-30 wt%, filming material 50-80 wt%, additive 1-10 wt% and some other supplementary material. It may be prepared into transdermal preparation, aerosol, oral liquid, eye preparation, tablet or capsule; is used in treating apoplexy, hemiplegia, atherosclerotic thrombotic cerebral infarction, cerebral embolism, etc.; and has excellent medicinal application foreground.

Description

technical field [0001] The invention relates to a liposome pharmaceutical preparation, more specifically, the invention relates to a liposome of total notoginseng saponins and a pharmaceutical preparation containing the total liposome of notoginseng saponins. Background technique [0002] Panax notoginseng is a plant of the genus Panax of Araliaceae, the root of which is used for medicine. So far, more than 20 kinds of monomeric saponins have been isolated from Panax notoginseng, with an average total glycoside content of 7.87%, and main medicinal active ingredients such as flavonoids 0.38%, notoginseng 0.90%, and active polysaccharides 0.28%. In addition, there are more than 17 kinds of amino acids in Panax notoginseng, with an average content of 7.73%, 0.40% of 73 kinds of volatile oil components, 17 kinds of trace elements including active selenium, and up to 8.8% of crude protein and other chemical substances. The content of total saponins in P...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K9/127A61K9/20A61K9/48A61K31/704A61P7/02A61P9/10A61P27/02
Inventor 周志宏梅艳熊毅
Owner YUNNAN PHYTOPHARML
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