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Ivermectin slow-release injecta, and preparing process and use method thereof

An injection preparation and ivermectin technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of no long-term continuous insecticidal effect, short drug effect time, etc., and achieve the overcoming effect. The effect of short time, low toxic and side effects, and high safety

Inactive Publication Date: 2005-04-20
陈坚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The invention provides an ivermectin sustained-release injection and its preparation process and use method, which solves the difficult problems of the existing conventional preparations of ivermectin that have short drug effect time and no long-term sustained insecticidal effect

Method used

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  • Ivermectin slow-release injecta, and preparing process and use method thereof
  • Ivermectin slow-release injecta, and preparing process and use method thereof
  • Ivermectin slow-release injecta, and preparing process and use method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1, the ivermectin sustained-release injection contains by weight percentage: 5% ivermectin, 5% ethyl acetate, 1% aluminum monostearate and the rest castor oil for injection.

Embodiment 2

[0029] Example 2, the ivermectin sustained-release injection contains by weight percentage: 5% ivermectin, 15% ethyl acetate, 5% aluminum monostearate and the rest castor oil for injection.

Embodiment 3

[0030] Example 3, the ivermectin sustained-release injection contains by weight percentage: 5% ivermectin, 5% ethyl acetate, 5% aluminum monostearate and the rest castor oil for injection.

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PUM

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Abstract

The invention relates to an ivermectin sustained-release injection used for preventing and treating parasitic diseases of livestock and poultry, and a preparation process and application method thereof. The ivermectin sustained-release injection contains by weight percentage: 5% ivermectin, 5 to 15% ethyl acetate, 1 to 5% aluminum monostearate and the rest castor oil for injection ; Its preparation process is: the preparation of aluminum monostearate-castor oil gel, the preparation of ivermectin sustained-release injection; its use method is to inject 0.05 to 0.10 milliliters or 2.5 milliliters per kilogram of body weight in animals. to 5.0 mg of ivermectin sustained-release injection. The ivermectin sustained-release injection of the present invention not only maintains the characteristics of the existing conventional preparations of ivermectin, such as broad-spectrum, high efficiency, low toxicity and side effects, high safety, and minimal impact on the environment, but also overcomes its short action time. The disadvantage of this invention is that the ivermectin sustained-release injection of the present invention is injected subcutaneously in the neck of the animal to form a depot, and the drug is slowly released for 100 days, which is convenient for administration, safe and effective.

Description

technical field [0001] The invention relates to an injection for preventing and treating parasitic diseases of livestock and poultry, a preparation process and a use method thereof, and relates to an ivermectin sustained-release injection and a preparation process and a use method thereof. Background technique [0002] In 1976, Merk Company obtained a family (8 kinds) of novel compounds from the fermented broth of the new species of actinomycetes Streptomyces avermitilis, and named them Avermectins (Avermectins, AVM). Its chemical structure and components are: [0003] [0004] AVM R 1 X-Y R 2 [0005] A1a CH 3 CH=CH C 2 h 5 [0006] A1b CH 3 CH=CH CH 3 [0007] A2a CH 3 CH 2 -CH(OH)C 2 h 5 [0008] A2b CH 3 CH 2 -CH(OH)CH 3 [0009] B1a H CH=CH C 2 h 5 [0010] B1b H CH = CH CH 3 [0011] B2a H CH 2 -CH(OH)C 2 h 5 [0012] B2b H CH 2 -CH(OH)CH 3 [0013] C of the abamectin co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/7048A61P33/00
Inventor 陈坚李新霞王岩任丽君
Owner 陈坚
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