Method for preparing high-purity acarbose

Abstract

A process for preparing high-purity Acarbose includes such steps as heating the fermented Acarbose liquid for sterilizing, primary membrane separation, cooling, regulating pH value, desalting and decolouring, regulating pH value, stage-one membrane separation, stage-2 membrane purifying, concentrating, regulating pH value, macroreticular resin adsorption, pickling, collecting high-purity (98%) solution of Acarbose, regulating pH value, stage-3 membrane purifying, concentrating and drying. Its advantages are high extraction rate, less environmental pollution and low cost.

Description

technical field [0001] The invention relates to a method for preparing acarbose, in particular to a method for preparing high-purity acarbose using membrane technology. Background technique [0002] Acarbose (Acarbose) is a kind of α-glucosidase inhibitor, molecular weight is 650, can be used as the anti-diabetic drug of oral treatment type II diabetes, and trade name is Bai Sugar Ping. The active compound is produced by fermentation, and the produced strain is actinomycetes SE50 / 110 or its derivative mutant. Acarbose must be separated from the broth after fermentation to produce a pure product. [0003] The content of active compounds of acarbose in the fermentation broth is not high, about 1500 micrograms per milliliter, and the current separation and purification technology uses ion resins with different structures to adsorb and purify acarbose. For this reason, German patent specification No. 2347782, No. 2719912 and Chinese patent specificat...

AI Technical Summary

Problems solved by technology

[0005] This method has the disadvantages of low yield of active ingredients of acarbose in the separation process, high cost of preparation method, high labor intensity, high energy consumption, large amount of resin used, and serious acid-base pollution.

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