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Polyhydroxybutyrate/polyglycol porous scaffold material and its preparation method

A technology of polyhydroxybutyrate and porous scaffolds, which is applied in medical science and prostheses, can solve the problems of unfavorable cell adhesion and growth, poor hydrophilicity, etc., and achieve controllable pore size and distribution, low price, and biological good compatibility

Inactive Publication Date: 2004-09-29
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the hydrophilicity of pure PHB material is poor, which is not conducive to the adhesion and growth of cells on the surface of the material.

Method used

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  • Polyhydroxybutyrate/polyglycol porous scaffold material and its preparation method
  • Polyhydroxybutyrate/polyglycol porous scaffold material and its preparation method
  • Polyhydroxybutyrate/polyglycol porous scaffold material and its preparation method

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Experimental program
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Effect test

Embodiment Construction

[0016] 1. Take the molecular weight as 4×10 5 4g of polyhydroxybutyrate and 0.4g of polyethylene glycol with a molecular weight of 6000,

[0017] 2. Put it in 80ml chloroform and stir for 2 hours at 40°C. After the solution is completely dissolved, transfer the solution to a 100ml volumetric flask, add the chloroform solution to obtain 100ml polyhydroxybutyrate / polyethylene glycol chloroform solution (A); take Dissolve 0.12g of SPAN60 in 60ml deionized water at 70℃ to obtain a stable template emulsion (B); take 20ml of solution (A) and 0.5ml of (B) and mix together, stir at 700 rpm for 3 hours, and wait until the solution is mixed After being uniformly stabilized, transfer to a 60mm glass petri dish, and place it in a low-temperature refrigerator at -80°C for pre-freezing for 24 hours; control the temperature of the drying chamber of the freeze dryer to -50°C, and move the petri dish containing the pre-frozen body into the drying chamber; After equilibrium, seal the drying chamber...

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Abstract

The present invention relates to a kind of polyhydroxy butyrate / polyethylene glycol porous scaffold material and its preparation method. Said invention is aimed at improve hydrophily of PHB and raising controllability of its pore size and distribution. Said invention adopts the polyhydroxy butyrate and polyethylene glycol as base material, and utlizes template method and freeze-drying method combination to make preparation. The voidage of its scaffold is dependent on the concentration of primary solution, and the mean pore size and pore size distribution also are influenced by prefreezing temp. Said invented porous scaffold material possesses good biological compatibility, and is specially-suitable for attachment and growth of soft bone tissue cell.

Description

Technical field [0001] The invention belongs to a porous scaffold used in the field of biomedical material science and engineering. Background technique [0002] Tissue engineering is an emerging discipline that uses the basic principles of engineering science and life science to research and develop biological substitutes to restore, maintain and improve tissue functions. The basic idea is to separate and culture cells in vitro, plant a certain amount of cells into a three-dimensional biomaterial skeleton with a certain shape, and continue to cultivate them, and finally form tissues and organs with a certain structure and return them to the body for repair or The purpose of reconstruction. Polyhydroxybutyrate (PHB) is a macromolecular polymer stored in the cells of microorganisms under unbalanced growth conditions. It is widely present in many prokaryotes in nature. PHB has many excellent biological and physical and chemical properties, such as: biod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56
Inventor 成国祥蔡志江王玲张立广
Owner TIANJIN UNIV
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