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Method for preparing degradable biologically active artificial bone

A bioactive, artificial bone technology, applied in the field of bone repair materials, can solve the problems of weak, slow, and unfavorable new bone reconstruction and remodeling, and achieve good bone repair ability, improve bone repair ability, and promote degradation. Effect

Inactive Publication Date: 2004-09-15
SUZHOU BC TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, CPC does not induce osteogenesis, but forms osteogenesis through osteoconduction, so the osteogenesis ability is weak
In addition, the degradation performance of CPC is not ideal, and it is significantly slower than biological materials such as allograft bone, which is not conducive to the new bone reconstruction and remodeling in the later stage of repair when it is used to treat large bone defects

Method used

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  • Method for preparing degradable biologically active artificial bone
  • Method for preparing degradable biologically active artificial bone
  • Method for preparing degradable biologically active artificial bone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: According to the technical scheme of the present invention, utilize the method of the prior art, adopt the liquid-phase precipitation reaction under the acidic condition to prepare calcium dihydrogen phosphate, tricalcium phosphate, tetracalcium phosphate and fluorapatite in the CPC solid phase composition stone. Then prepare the CPC / BMP composite artificial bone according to the following method:

[0021] 1) Take different solid phase powders and prepare a mixture with a calcium / phosphorus atomic ratio of 1.75:1 according to calculation. Weigh 3 g of the mixture for later use.

[0022] 2) Weigh 50 mg of artificially extracted bovine BMP, add 1.5 ml of 0.05 mmol / L phosphoric acid solution, and place at 4° C. for 8 hours to soften the dry BMP product. Aseptically triturate to a suspension.

[0023] 3) Mix the solid phase mixture with the solidification liquid containing BMP, mix it into a paste, and leave it at room temperature for 30 minutes to obtain a...

Embodiment 2

[0026] Example 2: CPC and CPC / BMP composite artificial bone were prepared according to the method of the present invention, and the two porosity were measured by drainage method. The results showed that after composite BMP, the porosity of the material increased from 39.0% to 44.5%. The calcium-to-phosphorus ratio of the two materials was determined by energy dispersion analysis X-ray (EDAX) method, and the results showed that they were both 1.75:1. It shows that the compounding of BMP has no effect on the ratio of calcium to phosphorus.

Embodiment 3

[0027] Example 3: CPC / BMP composite artificial bone was prepared according to the method of the present invention, implanted in the femoral musculature of mice, and the materials were taken at different times after surgery, sliced ​​and stained after fixation, and the osteoinductive activity and degradation characteristics of the materials were observed under a microscope. Results: After 1 week of CPC / BMP implantation, a large number of chondrocytes were formed in a mass, surrounded by many differentiated and proliferating mesenchymal cells (see image 3 ); after 2 weeks, chondrocytes differentiated into woven bone, and many immature woven bone and chondrocyte clusters were seen to migrate to each other, and a small amount of fibrous tissue was divided between the woven bone and the material (see Figure 4 ); after 4 weeks, woven bone transformed into trabecular bone, hematopoietic bone marrow tissue appeared, and there was still a small amount of new cartilage cell mass; after...

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Abstract

The preparation process of degradable bioactive artificial bone includes liquid phase deposition reaction in acid condition to prepare superfine high-purity solid CPC component; high temperature solid-solid reaction to generate solid CPC system; and liquid phase recombination to combine BMP into inside of CPC to protect the bioactivity of BMP and to distribute BMP homogeneously inside solidified CPC, with BMP being released slowly with the formation of new bone and the degradation of the material after being transplanted into body. The artificial bone may be used in the treatment of fracture, osteodiastasis, bone defect, osteoprosis and other diseases. The artificial bone may be also used in treatment of animal's fracture.

Description

1. Technical field [0001] The invention relates to a bone repair material for clinical medical application, in particular to a degradable biological activity using calcium phosphate bone cement as a carrier for clinical fracture, nonunion, bone defect and other diseases, which can be used in veterinary medicine Method for the preparation of artificial bone. 2. Background technology [0002] An ideal bone graft material should have the following characteristics: (1) Good biocompatibility. (2) It has a certain three-dimensional structure and mechanical strength. (3) It can be completely absorbed and the degradation rate is suitable. (4) It is easy to use and can be arbitrarily shaped or injected. (5) Wide range of sources and low prices. At present, a variety of materials have been used as artificial bone grafts, such as metal materials, bioceramics, hydroxyapatite, etc., but most of these materials have different shortcomings and are difficult to fully meet the requiremen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/28A61K38/18A61L27/12
Inventor 孙明林李涤尘
Owner SUZHOU BC TECH
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