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Fingertip contact type noninvasive sweat glucose sensor based on MOFs (Metal-Organic Frameworks) and method

A glucose sensor and contact technology, applied in the field of biosensors, to reduce costs, improve glucose detection accuracy, and relieve pain

Pending Publication Date: 2022-06-24
UNIV OF ELECTRONICS SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the existing problems about blood sugar detection; the purpose of the present invention is to provide a contact sweat glucose sensor based on MOFs, which can reflect the blood sugar value of the human body by measuring the glucose content in sweat through the electrodes of the electrochemical sensor, and will not affect the blood sugar level of the human body. Human body is damaged

Method used

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  • Fingertip contact type noninvasive sweat glucose sensor based on MOFs (Metal-Organic Frameworks) and method
  • Fingertip contact type noninvasive sweat glucose sensor based on MOFs (Metal-Organic Frameworks) and method
  • Fingertip contact type noninvasive sweat glucose sensor based on MOFs (Metal-Organic Frameworks) and method

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Effect test

Embodiment 1

[0040] like figure 1 As shown, this embodiment provides a fingertip contact type non-invasive sweat glucose sensor based on MOFs, including a substrate, a three-electrode system, and the three-electrode system includes a working electrode 11, a reference electrode 12 and a compensation electrode 13, and the working electrode 11 is at least Polymetallic-MOFs prepared from two transition metals and organic ligands.

[0041] The preparation method of fingertip contact non-invasive sweat glucose sensor based on MOFs is as follows: firstly, the electrode material is prepared by reacting at least two transition metal salt solutions, organic compound solution and carbon cloth, washing and drying, and then the adhesive is fixed. on the working electrode.

[0042] The reference electrodes were silver and silver chloride materials; the base material of the three-electrode system was polyethylene terephthalate.

[0043] The upper part of the three-electrode system is a ring structure, ...

Embodiment 2

[0061] This embodiment provides a fingertip contact non-invasive sweat glucose sensor based on MOFs, including a substrate and a three-electrode system. The three-electrode system includes a working electrode 11, a reference electrode 12 and a compensation electrode 13, and the working electrode 11 is at least two transitions Polymetallic-MOFs prepared from metals and organic ligands.

[0062] The preparation method of fingertip contact non-invasive sweat glucose sensor based on MOFs is as follows: firstly, the electrode material is prepared by reacting at least two transition metal salt solutions, organic compound solution and carbon cloth, washing and drying, and then the adhesive is fixed. on the working electrode.

[0063] The reference electrodes were silver and silver chloride materials; the base material of the three-electrode system was polyethylene terephthalate.

[0064] The upper part of the three-electrode system is a ring structure, and the ring structure is the ...

Embodiment 3

[0079] This embodiment provides a fingertip contact non-invasive sweat glucose sensor based on MOFs, including a substrate and a three-electrode system. The three-electrode system includes a working electrode 11, a reference electrode 12 and a compensation electrode 13, and the working electrode 11 is at least two transitions Polymetallic-MOFs prepared from metals and organic ligands.

[0080] The preparation method of fingertip contact non-invasive sweat glucose sensor based on MOFs is as follows: firstly, the electrode material is prepared by reacting at least two transition metal salt solutions, organic compound solution and carbon cloth, washing and drying, and then the adhesive is fixed. on the working electrode.

[0081] The reference electrodes were silver and silver chloride materials; the base material of the three-electrode system was polyethylene terephthalate.

[0082] The upper part of the three-electrode system is a ring structure, and the ring structure is the ...

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Abstract

The invention relates to a fingertip contact type noninvasive sweat glucose sensor based on MOFs (Metal-Organic Frameworks) as well as a preparation method and a detection method of the fingertip contact type noninvasive sweat glucose sensor. According to the fingertip contact type noninvasive sweat glucose sensor, after a three-electrode system is formed on a substrate through a printed circuit, a working electrode and a reference electrode are modified respectively; wherein the working electrode is mainly composed of carbon cloth coated with MOFs nanosheets prepared by adopting a solvothermal method, the reference electrode is composed of Ag / AgCl, and the three-electrode system is provided with an insulating protective layer except a working area. On the basis of utilizing the MOFs material, the fingertip contact type noninvasive sweat glucose sensor is prepared, the detection result of the sensor is similar to the result of a commercial blood glucose detector, no damage is caused to the human body, and the sensor has huge potential in practical application.

Description

technical field [0001] The invention relates to the field of biosensors, in particular to a fingertip contact type non-invasive sweat glucose sensor based on MOFs and a preparation method and detection method thereof. Background technique [0002] Glucose is one of the important metabolites and main nutrients in the human living system. However, glucose levels in the human body must be maintained within a certain range, and either too high or too low can lead to serious health hazards, and in some cases even life-threatening. According to the International Diabetes Federation (IDF), one person dies from diabetes-related complications worldwide on average every seven seconds, making diabetes one of the leading causes of death worldwide . Therefore, the effective detection of glucose in body fluids is of great significance for the early diagnosis and treatment of life-threatening diabetes and its related complications. [0003] Although the current household portable blood ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1477
CPCA61B5/14532A61B5/14517A61B5/1477
Inventor 杨亚杰查小婷石柳蔚曾琪赵梓涵谭放陈析蒋银辉徐建华
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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