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Application of miltirone in treatment of osteoarthritis

A technology for osteoarthritis and tanshinone, applied in the field of biomedicine, can solve problems such as no osteoarthritis

Pending Publication Date: 2022-05-31
LUOYANG ORTHOPEDIC TRAUMATOLOGICAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to further develop new drugs, it is necessary to determine possible active ingredients and possible targets. Tanshinone is a compound isolated and purified from Danshen, an important ingredient in this prescription. At present, there is no relationship between this compound and osteoarthritis. According to the report of the relationship, we used transcriptomics and network pharmacology analysis, combined with in vitro experimental studies, found that tanshinone is one of the active ingredients of Zhuanggu Huoxue Decoction, through its potential target JUN, tanshinone can effectively Reducing the expression of genes that promote cartilage degradation induced by inflammatory factors provides a definite theoretical basis for the clinical application of tanshinone

Method used

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  • Application of miltirone in treatment of osteoarthritis
  • Application of miltirone in treatment of osteoarthritis
  • Application of miltirone in treatment of osteoarthritis

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Embodiment Construction

[0019] It should be noted that, in the case of no conflict, the following embodiments and the features in the embodiments can be combined with each other. return

[0020] When the examples give numerical ranges, it is to be understood that, unless otherwise specified in the present invention, both ends of each numerical range

[0022] Methods: Gene screening data were searched in the NCBI Gene Expression Database (GEO). Choose the one that meets the experimental requirements

[0025]

[0033]

[0035] Methods: To explore small molecules with biological roles. We consult the analytical results of the BATMAN‑TCM database

[0041] Results: Tanshinone significantly affected the minimum treatment concentration of cell viability ≥ 5 μg / ml (as shown in Figure 5). 0.5μg /

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Abstract

The invention relates to application of miltirone in treatment of osteoarthritis. The tanshinone can effectively reduce the expression of chondrolysis promoting genes such as MMP3 and MMP13 secreted by synovial fibroblasts induced by inflammatory factors through a potential action target JUN of the tanshinone, which indicates that the tanshinone has a new application in treating osteoarthritis.

Description

Use of tanshinone in the treatment of osteoarthritis technical field [0001] The present invention relates to the technical field of biomedicine, particularly to the use of tanshinone in the treatment of osteoarthritis. Background technique Osteoarthritis (OA) is a progressive damage to articular cartilage and changes in subchondral bone It is characterized by common bone diseases that seriously affect the physical health and quality of life of the elderly, among which, knee osteoarthritis It is the most common arthritic disease and is associated with a variety of pathological changes in the joints. Although the pathogenesis of osteoarthritis is complex, Available evidence suggests that synovitis plays a key role in the progression of osteoarthritis and may even be a contributor to the pathogenesis of osteoarthritis independent drivers. Therefore, exploring the causative genes of synovitis in osteoarthritis and finding effective therapeutic drugs have become top pr...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P19/02G16B50/30G16B15/30G16B45/00
CPCA61K31/122A61P19/02G16B50/30G16B15/30G16B45/00
Inventor 郑振雨郭马珑崔宏勋
Owner LUOYANG ORTHOPEDIC TRAUMATOLOGICAL HOSPITAL
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