Spinal cord half-cutting device and half-cutting method for manufacturing animal spinal cord injury model

Abstract

The invention discloses a spinal cord semi-cutting device and a semi-cutting method for manufacturing an animal spinal cord injury model.The spinal cord semi-cutting device comprises a spinal cord semi-cutting device body and a main control center, and the main control center is arranged outside the spinal cord semi-cutting device body and used for controlling actions of the spinal cord semi-cutting device body; the spinal cord half-cutting device body comprises a fixing frame, a half-cutting driving mechanism, a spinal cord fixing structure and a cutting assembly, the half-cutting driving mechanism is arranged on the fixing frame, and the cutting assembly is installed on the half-cutting driving mechanism in a lifting mode; after the fixing frame is erected above a non-human primate to be modeled and an epidural opening is cut through an artificial incision operation, the spinal cord fixing structure penetrates into the gap between the spinal cord and the epidural and surrounds the periphery of the spinal cord, the half-cutting driving mechanism is located above an incision and drives the cutting assembly to act, and the spinal cord fixing structure half cuts the spinal cord. Excessive dura mater cannot be damaged, and postoperative maintenance is facilitated.

Description

technical field [0001] The invention relates to the technical field of equipment for making spinal cord injury models of non-human primates, in particular to a spinal cord hemisection device and method for making animal spinal cord injury models. Background technique [0002] Collecting research data from experimental animals is an extremely important part of medical experiments that focus on research on a specific disease, such as research on spinal cord injuries. For spinal cord injury, the more suitable experimental animals are monkeys. Among them, to study the mechanism of spinal cord injury and its treatment, it is very important to make an animal spinal cord injury model through monkeys. [0003] At present, there are mainly the following animal spinal cord injury models: including hemostat clamp method spinal cord crush injury model, heavy object falling method spinal cord injury model, spinal cord transection injury model, spinal cord hemisection injury model, balloo...

AI Technical Summary

Problems solved by technology

However, the existing spinal cord hemisection injury model is usually made by manual half-section. It is difficult to grasp the cutting depth when the spinal cord is half-cut with a hand-held scalpel. The spinal cord is surrounded by dura mater. After the dura mater is cut Then perform a hemisection of the spinal cord, that is, cut off half of the spinal cord column. However, it is easy to cut the dura mater during the hemisection of the spinal cord. Therefore, manual hemisection is not only difficult to cut the spinal cord flat, but also cuts too much dura mater during the hemisection. , making postoperative maintenance difficult

In addition, surgical modeling of large animals often requires extremely skilled surgical skills, and the modeling of spinal cord hemisection is extremely difficult, which is a big problem for researchers who have not received surgical training

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