Method, system and medium for integrally screening proteome clinical biomarkers

A biomarker and protein marker technology, applied in the field of overall biomarker screening, can solve the problems of unsatisfactory results of practical application of markers, weak screening ability of biomarkers, limited data mining and analysis ability, etc., and achieve efficient identification and analysis. Recognition verification rate, best prediction effect, high accuracy cost effect

Pending Publication Date: 2022-05-27
WUHAN GENECREATE BIOLOGICAL ENG CO LTD
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Problems solved by technology

[0004] The purpose of the present invention is to overcome the above-mentioned technical deficiencies, provide an overall screening method, system and medium for proteomic clinical biomarkers, and solve the problem of poor

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  • Method, system and medium for integrally screening proteome clinical biomarkers
  • Method, system and medium for integrally screening proteome clinical biomarkers
  • Method, system and medium for integrally screening proteome clinical biomarkers

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Embodiment Construction

[0039] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0040] It should be noted that although the functional modules are divided in the schematic diagram of the system and the logical sequence is shown in the flowchart, in some cases, the modules can be divided differently from the system, or executed in the order in the flowchart. steps shown or described. The terms "first", "second", etc. in the description and claims and the above drawings are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence.

[0041] The present invention provides an overall screening method for proteomic clinical ...

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Abstract

The invention provides a proteome clinical biomarker overall screening method and system and a medium, and the method comprises the following steps: obtaining detection data of a high-throughput proteome, and carrying out data preprocessing on the detection data; carrying out proteomics feature pre-screening on the preprocessed detection data to obtain a proteomics effective feature set; performing feature extraction on the effective feature set to obtain a candidate protein marker combination; and screening the candidate protein marker combination by using a plurality of machine learning feature selection methods to obtain the biomarker. The method can be used for screening potential biomarkers with high throughput, high sensitivity, high accuracy and reasonable cost from mass data. The biomarker diagnosis with high verification rate and remarkable classification effect can be efficiently identified and identified, so that the time, energy and resources of related researchers can be greatly saved, and great convenience is provided for the related researchers.

Description

technical field [0001] The present invention relates to the technical field of overall screening of biomarkers, in particular to a method, system and medium for overall screening of proteomic clinical biomarkers. Background technique [0002] Biomarkers have a wide range of applications in the fields of translational medicine and clinical, ecology and environment, and physiological mechanism research. The importance of biomarkers has long been recognized by the public, scientific community and industry. Biomarkers can be applied to the classification, prediction, treatment and prevention of diseases. They are the basis for the pre-translation of clinical applications, and are also important indicators for early screening. However, the number of protein biomarkers actually approved by the Food and Drug Administration is not large, and there are fewer protein biomarkers in routine clinical use. Gaps between clinically defined and objective protein test results, and high fals...

Claims

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Application Information

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IPC IPC(8): G16B40/00G06N20/20
CPCG16B40/00G06N20/20Y02A90/10
Inventor 赵海义华权高李云舒芹张韦
Owner WUHAN GENECREATE BIOLOGICAL ENG CO LTD
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