Cell factor model for prognosis evaluation of malignant pleural effusion patient and application

Abstract

The invention belongs to the field of diagnosis and treatment of malignant pleural effusion related diseases, and relates to a cytokine model for prognosis evaluation of a malignant pleural effusion patient and application. According to the cell factor model, the cell factor score CRPI is equal to n1 * x1 + n2 * x2... n32 * x32; wherein n1-n32 are coefficients shown in the table 1 in sequence, and x1-x32 are relative expression quantities of the cell factors in the table 1 in sequence. The prognosis evaluation device comprises a detection unit and an analysis unit, the detection unit is used for detecting the relative expression quantity of cell factors in a sample; the analysis unit takes the relative expression quantity of cell factors as an input variable, inputs the input variable into the prediction model, and analyzes the prognosis state of the malignant pleural effusion patient; the equation of the prediction model is the above formula. The cell factor model for prognosis evaluation of the malignant pleural effusion patient or the prognosis evaluation device is applied to preparation of a malignant pleural effusion prognosis diagnosis reagent. According to the method, the prediction model is constructed by taking the relative expression quantity of the cell factors as an input variable, and the benign and malignant prognosis of the malignant pleural effusion patient can be accurately predicted.

Description

technical field [0001] The invention belongs to the field of diagnosis and treatment of malignant pleural effusion-related diseases, and particularly relates to a cytokine model and application for prognosis evaluation of patients with malignant pleural effusion. Background technique [0002] Malignant pleural effusion (MPE) refers to pleural effusion caused by malignant tumor originating in the pleura or metastasis of malignant tumor from other parts to the pleura. Lung adenocarcinoma is a common cause of MPE, and the appearance of MPE indicates that the tumor has spread to an advanced stage and lacks effective treatment. Therefore, establishing a simple method for analyzing some clinical indicators and laboratory test results of MPE patients, so as to judge their prognosis quickly and accurately, is very important for the clinical treatment of MPE patients. A large number of lymphocytes, pleural mesothelial cells, endothelial cells, fibroblasts and tumor cells were enrich...

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Problems solved by technology

[0003] In view of the above problems, the present invention provides a cytokine model and its application for the prognosis assessment of patients with malignant pleural effusion, which mainly solves the problems of low accuracy of existing prognostic detection methods

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