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Methods and products for treating gastrointestinal disorders

A technology for gastrointestinal diseases and diseases, applied in the direction of medical raw materials derived from bacteria, biochemical equipment and methods, and disease diagnosis, which can solve the problems of failing to reduce the relative risk of CDI recurrence

Pending Publication Date: 2022-05-17
FINCH THERAPEUTICS HLDG LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug failed to reduce the relative risk of CDI recurrence compared with placebo for up to eight weeks after treatment

Method used

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  • Methods and products for treating gastrointestinal disorders
  • Methods and products for treating gastrointestinal disorders
  • Methods and products for treating gastrointestinal disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0640] Embodiment 1: A pharmaceutical composition comprising a mixture of at least two bacterial isolates, wherein at least one of said bacterial isolates comprises at least 95% of the 16S rRNA sequence of the bacterial isolates provided in Table 1 16S rRNA sequence of identity, and wherein said at least two bacterial isolates are isolated from stool samples of different donors.

Embodiment approach 2

[0641] Embodiment 2: The pharmaceutical composition of Embodiment 1, wherein at least two of said bacterial isolates comprise a 16S rRNA having at least 95% identity to the 16S rRNA sequence of the bacterial isolates provided in Table 1 sequence.

Embodiment approach 3

[0642] Embodiment 3: The pharmaceutical composition of Embodiment 1 or Embodiment 2, wherein at least three of said bacterial isolates comprise a 16S rRNA sequence at least 95% identical to the bacterial isolates provided in Table 1 Sexual 16SrRNA sequence.

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PUM

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Abstract

Described herein are compositions and methods for delivering microbial therapeutic agents useful for the treatment of conditions associated with dysbacteriosis of intestinal flora. Described herein are compositions and methods for protecting the gastrointestinal microbiome in a subject. In various embodiments, provided herein are pharmaceutical compositions comprising isolated or purified bacterial isolates and / or mixtures of isolated or purified bacterial isolates (e.g., faeces from humans, e.g., from healthy humans).

Description

[0001] priority [0002] This application claims the benefit of and priority to U.S. Provisional Application No. 62 / 876,358, filed July 19, 2019, the contents of which are incorporated herein by reference in their entirety. technical field [0003] The present invention relates, in part, to compositions and methods for delivering bacterial isolates and / or mixtures of bacterial isolates useful for the treatment of disorders associated with intestinal dysbiosis. [0004] Instructions for text files submitted electronically [0005] This application contains a Sequence Listing. The Sequence Listing is submitted electronically via EFS-Web as an ASCII text file entitled "FIN-020PC_ST25". The size of the sequence listing is 61,430 bytes and was prepared on or about July 19, 2019. This Sequence Listing is incorporated herein by reference in its entirety. Background technique [0006] The human gastrointestinal tract is home to more than a thousand different bacterial species an...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P1/00G01N33/68G01N33/92
CPCA61K35/74A61P1/00A61P29/00G01N2333/5428G01N2333/5434G01N2333/5255G01N33/6863C12Q1/025G01N2800/065G01N33/5047G01N33/5023
Inventor M·史密斯A-T·E·微欧R·萨多夫斯基J·亨斯克Y·杰拉尔丁S·提姆布莱克
Owner FINCH THERAPEUTICS HLDG LLC
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