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Wave color factor detection method and application

A detection method, Bosein technology, applied in the field of analysis and detection, can solve the problems of limited sample consumption in sample price detection, inability to determine sample purity, inability to accurately locate molecular peaks, etc., to achieve efficient detection and avoid sample consumption.

Active Publication Date: 2022-05-13
BIOISLAND LAB +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the one hand, as an expensive synthetic molecule, the sample price of Bosein and the sample consumption available for detection are limited; secondly, in terms of detection sensitivity and purity interpretation, the result given by ESI-API is a complex multi-peak spectrum Figure, the peak results detected by Bosein in the positive ion mode of ESI-API are shown in the appendix figure 1 As shown, it can be seen that the result has obvious complexity in the peak output, which is a complex multi-peak spectrum
Based on this peak spectrum, individual molecular peaks cannot be precisely located, and the purity of the sample cannot be determined from the spectrum

Method used

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  • Wave color factor detection method and application
  • Wave color factor detection method and application

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Embodiment 1

[0052] This embodiment provides a detection method for boseine, with boseine hydrate 30% as the detection object, using P25 TiO 2 As the matrix, MALDI-TOF MS was used for detection.

[0053] The detection steps are as follows:

[0054] (1) Take 1 μL of a 30% sample of Bosein Hydrate, dilute it 100 times with 0.1% (wt%) TFA aqueous solution, and then place it at room temperature for use.

[0055] (2) mix absolute ethanol with mass percent concentration of 0.85% sodium chloride aqueous solution with a volume ratio of 1:1 to make a mixed solvent; P25 TiO 2 Disperse into a mixed solvent, ultrasonic for 15 minutes, and maintain a suspension state. If there is precipitation, it can be ultrasonically mixed again to make a matrix dispersion system P25 TiO with a concentration of 10mg / mL 2 (10 mg / mL, 50% Ethanol x 0.85% NaCl).

[0056] (3) Mix the Bosein diluted sample with the matrix dispersion system, the volume ratio of the Boseine diluted sample to the matrix dispersion system i...

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Abstract

The invention belongs to the technical field of analysis and detection, and particularly discloses a wave color factor detection method and application of the wave color factor detection method. According to the method, the sample treatment mode and the detection means are optimized aiming at the detection of the glassine small molecules, and the efficient detection of the glassine small molecules is realized through the nano-matrix pretreatment co-crystallization and the MALDI-TOF MS detection means. According to the method, consumption of a large number of samples can be avoided, and repeated detection can be carried out; the molecular mass spectrum result obtained through detection can directly give clear glass color peak appearance information, and the purity of the sample can be clearly judged through the single peak shape.

Description

technical field [0001] The present invention relates to the technical field of analysis and detection, in particular to a bosine detection method, and also relates to the application of the detection method. Background technique [0002] Pro-Xylane is a xylose derivative with anti-aging active substances. Its structural formula is as follows. It can promote the synthesis of collagen, make the skin stronger and more elastic, improve fine lines on the neck, and prevent aging. Bosein was originally successfully developed by L'Oreal in 2006, and has been used in the development and production of various skin care products. [0003] [0004] For the detection of Bosein molecules, electrospray mass spectrometry ESI is commonly used at present, such as ESI-API (atmospheric pressure ionization mass spectrometry), ESI-API is suitable for the analysis of small molecular organic compounds with medium polarity and weak polarity, and the sample needs to be in liquid state for soft io...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/64G01N1/28G01N1/38
CPCG01N27/64G01N1/28G01N1/38
Inventor 金佳薏宋合兴周晓光李运涛
Owner BIOISLAND LAB
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