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Application of PLK1 as target spot in preparation of medicine for treating Ebola virus diseases

An Ebola virus, PLK1 technology, applied in antiviral agents, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc., can solve problems such as virus infection applications that have not yet been reported, and achieve the effect of inhibiting proliferation

Active Publication Date: 2022-05-06
ANHUI UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although PLK1 is currently a popular target for tumor therapy, its application in viral infection has not been reported yet.

Method used

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  • Application of PLK1 as target spot in preparation of medicine for treating Ebola virus diseases
  • Application of PLK1 as target spot in preparation of medicine for treating Ebola virus diseases
  • Application of PLK1 as target spot in preparation of medicine for treating Ebola virus diseases

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Embodiment Construction

[0024] The application will be described in further detail below in conjunction with the accompanying drawings. It is necessary to point out that the following specific embodiments are only used to further illustrate the application, and cannot be interpreted as limiting the protection scope of the application. The content of the above application makes some non-essential improvements and adjustments to the present application.

[0025] 1. Materials

[0026] 1. Cell lines and plasmids

[0027] HEK293 cells are preserved in this laboratory, and can also be purchased from Guangzhou Yuanjing Biotechnology Co., Ltd. through commercial sales.

[0028] Ebola virus minimal genome system-related plasmids pCAGGS-NP, pCAGGS-VP35, pCAGGS-VP30, pCAGGS-L, p4cis-vRNA-Rluc, pCAGGS-Tim1 and pCAGGS-T7 are all described in the literature "Hoenen T, Watt A, Mora A,Feldmann H.Modeling the lifecycle of Ebola virus under biosafety level2conditions with virus-like particles containing tetracistron...

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Abstract

The invention belongs to the field of biological medicine, and particularly discloses application of PLK1 (serine / threonine kinase) as a target spot in preparation of medicine for preventing or treating Ebola virus diseases, serine / threonine kinase PLK1 is used as the target spot, Ebola virus inclusion body formation is remarkably reduced by inhibiting expression of PLK1, and Ebola virus proliferation in cells is effectively inhibited. The research result of the invention enables PLK1 to be expected to become a potential therapeutic target for Ebola virus infection, provides a new strategy for prevention and treatment of acute infectious diseases caused by Ebola virus infection, and has important application value in the aspects of drug research and development and vaccine development.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the application of PLK1 as a target in the preparation of drugs for preventing or treating Ebola virus disease. Background technique [0002] Ebola virus (EBOV) is a single-stranded negative-sense RNA virus, which is a filamentous virus that can cause Ebola hemorrhagic fever in humans and other primates. The Ebola River region was discovered, and there have been frequent outbreaks in Africa since then. According to WHO statistics, the largest outbreak was the 2014-2016 outbreak in West Africa, which caused about 11,300 deaths. Since then, the Congo ( The outbreak in eastern China resulted in 3,444 infections and 2,264 deaths, with a fatality rate between 60% and 90%. Today, with the increase of global population mobility, coupled with its characteristics of strong infectivity, high lethality, and susceptibility to genetic variation, global public health is still facing a hu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P31/14A61K31/496A61K31/44
CPCA61K45/00A61P31/14A61K31/496A61K31/44Y02A50/30
Inventor 柏宇刘海楠曹诚张部昌徐昌志张迅
Owner ANHUI UNIVERSITY
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