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Mouse spinal cord injury compound experiment device and use method thereof

An experimental device and spinal cord injury technology, which is applied in veterinary surgery, veterinary instruments, medical science, etc., can solve the problem that the small diameter of the mouse spinal cord is not easy to be clearly exposed, the single function of the mouse spinal cord injury model platform, and the inability to accurately hit or Problems such as compression of the spinal cord, to achieve the effect of saving procurement costs, good repeatability, and easy processing

Pending Publication Date: 2022-04-29
冯世庆 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a mouse spinal cord injury compound experimental device and its use method, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the problem that the existing mouse spinal cord injury model platform has a single function and cannot simulate both blunt trauma and trauma. It can simulate crush injury; and the small diameter of the mouse spinal cord is not easy to be clearly exposed, and the problem that the spinal cord cannot be hit or compressed accurately

Method used

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  • Mouse spinal cord injury compound experiment device and use method thereof
  • Mouse spinal cord injury compound experiment device and use method thereof
  • Mouse spinal cord injury compound experiment device and use method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment one: as attached figure 1 , 2 As shown in . 2. On the operating table 1 at the left position, there is provided a front container groove 3 with an opening upwards and an inclination of left low and right high, and the groove depth of the front container groove 3 is smaller than the groove depth of the rear container groove 2, and the middle part of the left end of the front container groove 3 There is a tapered hole with a lower left and a higher right, and a tapered hole with a large outer end and a smaller inner end. There is an air intake passage 4 connected between the bottom of the tapered hole and the middle part of the left side of the operating table 1; The operating table 1 at both sides is provided with a bracket whose left end is located on the left side of the front body groove 3, and the middle part of the bracket corresponding to the position between the front body groove 3 and the rear body groove 2 is provided with an adjustment hole 5 penetr...

Embodiment 2

[0037] Embodiment 2: the mouse spinal cord injury compound experimental device The method of use includes blunt trauma simulation experiment and compression injury simulation experiment. The preparation process is to first place the rear half of the anesthetized mouse on the slope at the left end of the rear shelter tank 2, Let the front half of the mouse hang down naturally in the front body groove 3, cover it with a tapered sleeve 17 so that the front end of the snout of the mouse is located in the air intake channel 4, and the back of the mouse is naturally covered by the front body groove 3 and the front body groove 3. The operating table 1 between the rear housing slots 2 is propped up to form an arch so that the spine of the mouse to be tested is raised; then the two front paws of the mouse are respectively fixed with the front paw fixing table 18, and the two hind paws are fixed with the back paws. Fix the claw fixing table 19 respectively, and connect the anesthesia gas...

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Abstract

The invention relates to the technical field of animal experiment instruments, in particular to a mouse spinal cord injury composite experiment device and a using method thereof. The latter comprises a blunt contusion simulation experiment and a compression injury simulation experiment. The device is reasonable and compact in structure and convenient to use, by arranging the needle cylinder and the striking piece, if the striking piece is put into the needle cylinder from the inner side of the upper end of the needle cylinder, after the striking piece does falling motion in the needle cylinder, the lower end of the striking piece strikes the spinal cord of a mouse to simulate blunt contusion, and the lower end of the striking piece directly presses the spinal cord of the mouse for a period of time to simulate compression injury; meanwhile, through the arrangement of the front accommodating body groove and the rear accommodating body groove, the spine of the mouse can be naturally bent, the spinal cord of the mouse can be more clearly exposed, accurate hitting or pressing of the hitting piece is achieved, repeated purchasing of related experimental equipment can be avoided by using the device, the purchasing cost is greatly saved, and related experiments conducted through the device are good in repeatability and high in practicability. And experimental data can be collected to establish a related experimental model.

Description

technical field [0001] The invention relates to the technical field of animal experiment equipment, and relates to a compound experimental device for spinal cord injury in mice and a method for using the same. Background technique [0002] Spinal cord injuries often occur in natural disasters such as major traffic and work accidents and earthquakes. After spinal cord injury, various motor, sensory, and sphincter dysfunctions, abnormal muscle tone, and pathological reflexes appear in the corresponding segments of the damage. Corresponding changes. The blunt trauma or crush model is close to the actual human spinal cord injury and is a good model for studying spinal cord injury. Blunt trauma is generally simulated by impacting the spinal cord with mechanical force, causing the spinal cord to produce elastic deformation under stress and causing injury. Injuries generally involve compressing the spinal cord by mechanical force for a period of time so that the spinal cord is inju...

Claims

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Application Information

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IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 冯世庆伊力扎提·伊力哈木迪力扎提·伊力哈木张文灿樊祥闯袁仲泽邱鹏王斌
Owner 冯世庆
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