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Pharmaceutical composition ethosome, gel, hydrogel ointment, patch and preparation method

A technology of alcohol body and composition, applied in the field of pharmaceutical preparation synthesis, can solve the problems of easy relapse administration, inconvenience, unsatisfactory treatment effect and the like, and achieve the effects of good compliance, convenient administration and lasting treatment effect

Pending Publication Date: 2022-04-22
南京星银药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention provides ethosome, a pharmaceutical composition for treating scars, to solve the problems of unsatisfactory therapeutic effect, easy relapse after drug withdrawal, and inconvenient administration of existing drugs for treating scars.

Method used

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  • Pharmaceutical composition ethosome, gel, hydrogel ointment, patch and preparation method
  • Pharmaceutical composition ethosome, gel, hydrogel ointment, patch and preparation method
  • Pharmaceutical composition ethosome, gel, hydrogel ointment, patch and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of pharmaceutical composition ethosome:

[0038] The composition of ethosomes:

[0039]

[0040] Ethosome preparation method:

[0041] (1) Weigh the amount of soybean lecithin and cholesterol dissolved in ethanol to obtain alcohol phase A;

[0042] (2) Weigh the formula amount of thymosin β4, triamcinolone acetonide, sodium deoxycholate, vitamin E and phenol and dissolve in PBS buffer to obtain aqueous phase B;

[0043] (3) Magnetically stir alcohol phase A and water phase B, and add water phase B to alcohol phase A at a temperature of 33°C; among them, use PBS buffer (phosphate buffered saline, phosphate buffered saline) The total weight of is 100%, and the adding speed of aqueous phase B is 3% / minute;

[0044] (4) Continue magnetic stirring under the same conditions, filter after hydration for 20 minutes, and obtain the ethosome of the pharmaceutical composition;

[0045] (5) Sizing the ethosomes of the obtained pharmaceutical composition by using a...

Embodiment 2-8

[0051] The preparation method of the ethosome gelling agent of the pharmaceutical composition of Examples 2-8 is the same as that of Example 1, except that the formulation of each component in the ethosome is shown in Table 1 for details.

[0052]

Embodiment 9

[0056] Encapsulation efficiency determination:

[0057] In this example, the ethosome encapsulation efficiency of the pharmaceutical composition obtained in Examples 1-8 was determined by low-temperature ultracentrifugation.

[0058] Precisely pipette 2.0 mL of ethosomes, the pharmaceutical composition obtained in Examples 1-8, into a centrifuge tube, centrifuge at a low temperature of 4°C and 14,000 rpm for 30 min, remove the supernatant, and fill up an equal amount of blank spacer. The supernatant (that is, the prepared supernatant with all components except the pharmaceutical composition removed), centrifuged for 30 minutes under the same conditions, removed and combined the supernatant, HPLC (High Performance Liquid Chromatography) Determination of the amount of the pharmaceutical composition in the supernatant is denoted as M; after the ethosomes of the pharmaceutical composition obtained by centrifugal sedimentation are demulsified (0.2mL methanol demulsification), the a...

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Abstract

The invention provides a pharmaceutical composition ethosome, which is prepared from the following components in percentage by weight: 0.1 to 0.2 percent of thymosin beta4, 0.5 to 1 percent of glucocorticoid, 30 to 50 percent of low-molecular-weight alcohol, 3.0 to 12.0 percent of phospholipid, 1.0 to 2.5 percent of cholesterol, 0.51 to 1.3 percent of auxiliaries and the balance of PBS (Phosphate Buffer Solution). The invention also provides a method for preparing the pharmaceutical composition ethosome for treating scars. According to the ethosome, the dosage of hormone can be reduced, side effects can be reduced, the treatment effect is more lasting, scars can be shrunk in the medication process, and after medication is stopped, the scars are not prone to relapse and reach 1 + 1gt; and 2, efficacy. The ethosome disclosed by the invention is strong in transdermal ability, high in encapsulation efficiency, large in drug loading capacity, good in stability and easy to store and use. In addition, the ethosome provided by the invention has toxic and side effects, and is convenient, safe and controllable in administration, good in compliance and higher in bioavailability.

Description

technical field [0001] The invention relates to the field of synthesis of pharmaceutical preparations, in particular to a pharmaceutical composition ethosome, gel, hydrogel ointment, and patch for treating scars, which has good therapeutic effect, few side effects, is not easy to relapse after drug withdrawal, and is convenient for administration. and preparation method. Background technique [0002] Scar tissue refers to fibrous connective tissue in the aging stage formed by remodeling and maturation of granulation tissue. In situations such as trauma, fibroblasts divide, proliferate, migrate to the damaged site, produce extracellular matrix, and form scar tissue, thereby repairing the wound. The formation of scar tissue is a process of gradual fibrosis of granulation tissue. At this time, there are more and more reticular fibers and collagen fibers, reticular fibers are collagenized, and collagen fibers become thicker. The lower ones transform into fibroblasts; the fluid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K38/22A61K47/10A61K47/18A61K47/32A61K9/70A61P17/02A61K31/573
CPCA61K9/1272A61K9/1277A61K38/2292A61K31/573A61K9/0014A61K9/7023A61K47/32A61K47/10A61K47/183A61P17/02A61K2300/00
Inventor 刘铠豪刘枫张利香
Owner 南京星银药业集团有限公司
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