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Application of songorine in medicine for resisting doxorubicin cardiotoxicity

A cardiotoxic and anti-adriamycin technology, applied in the field of medicine and biology, can solve problems such as applications that have not yet been reported, and achieve the effect of significant therapeutic effect, easy realization, and protection of myocardial mitochondrial function.

Pending Publication Date: 2022-04-12
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of songuoling in anti-adriamycin cardiotoxic drugs has not been reported yet.

Method used

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  • Application of songorine in medicine for resisting doxorubicin cardiotoxicity
  • Application of songorine in medicine for resisting doxorubicin cardiotoxicity
  • Application of songorine in medicine for resisting doxorubicin cardiotoxicity

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Experimental program
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Effect test

Embodiment Construction

[0025] The invention describes in detail the application of songuoling in anti-adriamycin cardiotoxic drugs.

[0026] 1. Cell-level evaluation of Song Guoling's anti-adriamycin cardiotoxicity

[0027] 1. Evaluation of cell viability

[0028] H9c2 cardiomyocytes were divided into 5×10 3 The density of cells / well was seeded on a 96-well plate, and then at 37°C, with a volume content of 5% CO 2 When the cell density is about 70% to 80% in a constant temperature incubator, the culture medium is discarded, and the culture medium containing different concentrations including 1 μM, 10 μM, 50 μM, and 100 μM songfruit is added, and the culture medium containing 2 μM doxorubicin is directly added after 6 hours. According to the preparation process of the sample group, adriamycin model group (2μM doxorubicin), normal control group (with cells, no doxorubicin) and blank control group (no cells, no doxorubicin) were set up. white). Continue to culture the above groups for 18 h, discard...

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Abstract

The invention discloses an application of songlin in a medicine for resisting doxorubicin cardiotoxicity, and particularly relates to an application of songlin in a medicine for resisting doxorubicin cardiotoxicity, resisting heart failure, increasing cardiac ejection fraction and protecting myocardial mitochondrial functions. According to the application disclosed by the invention, the songorine is applied to the medicine for resisting doxorubicin cardiotoxicity and heart failure, so that the cardiac ejection fraction is effectively increased, the myocardial cell apoptosis is prevented, the myocardial mitochondrial function is protected, the myocardial fibrosis is reduced, the tumor cell proliferation inhibition effect of doxorubicin is not reduced while the myocardial cell activity is increased, and the application treatment effect is remarkable; the traditional Chinese medicine composition has no obvious side effect and has a good medicinal prospect.

Description

technical field [0001] The invention belongs to the field of medical biology, and in particular relates to the application of songuoling in anti-adriamycin cardiotoxic drugs. Background technique [0002] Doxorubicin (DOX) is a high-efficiency, broad-spectrum anthracycline antineoplastic drug, and is currently one of the most effective core chemotherapy drugs in various chemotherapy regimens for solid tumors and hematological malignancies. However, in the course of clinical application, it has a strong damage effect on cardiomyocytes, resulting in cardiotoxicity of doxorubicin, which seriously restricts the clinical application of doxorubicin. Dexrazoxane (DEX) is the only drug approved by the US FDA to prevent cardiotoxicity of doxorubicin, but it may reduce the antitumor effect of anthracyclines and aggravate the bone marrow suppression caused by chemotherapy drugs. There is still considerable controversy regarding the clinical application strategy of dextropropanimine. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61P9/00A61P9/04
Inventor 谭光国丁欣张雅廖文婷周倩
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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