Drug balloon catheter and surface treatment method of drug balloon

Abstract

The invention discloses a medicine balloon catheter and a surface treatment method of a medicine balloon. The medicine balloon catheter comprises a catheter base, a catheter body, a balloon body, a pressure opening, a medicine coating and a protective coating. Comprising the following steps: S1, firstly preparing microspheres, weighing a certain amount of a carrier and a medicine, and dissolving in a solvent a to obtain a solution A; s2, preparing PVA or cellulose or a mixture aqueous solution thereof with the concentration of 2%-15% to obtain a solution B; the balloon has the advantages that the saturation degree and the conveying area of the drug coating on the balloon are effectively improved, the drug can be coated on the blood vessel wall through single expansion, the operation difficulty is effectively reduced, the operation time is shortened, meanwhile, the bioavailability is higher, the lasting tissue drug treatment concentration can be kept, and the application prospect is wide. And moreover, the loss of the medicine coating in the conveying process can be effectively prevented, and finally the purposes of improving the medicine utilization rate, reducing the medicine dosage and reducing the side effect of the medicine on the human body as much as possible are achieved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a drug balloon catheter and a surface treatment method for the drug balloon. Background technique [0002] Drug balloon is a new type of therapeutic balloon drug release technology developed on the basis of interventional techniques such as balloon dilatation or balloon angioplasty. It coats the surface of the balloon with anti-proliferative drugs, such as paclitaxel, When the balloon reaches the lesion site, the blood vessel wall is stretched and expanded, and when it comes into contact with the intima of the blood vessel wall, the drug is rapidly released and transferred in the local blood vessel wall. In order to prevent vascular restenosis after vascular intervention, the drug coating on the existing drug balloon mostly uses polymer as the carrier. Due to the large size of the polymer carrier, the saturation of the drug on the balloon and the drug delivery area are re...

AI Technical Summary

Problems solved by technology

[0002] Drug balloon is a new type of therapeutic balloon drug release technology developed on the basis of interventional techniques such as balloon dilatation or balloon angioplasty. It coats the surface of the balloon with anti-proliferative drugs, such as paclitaxel, When the balloon reaches the lesion site, the blood vessel wall is stretched and expanded, and when it comes into contact with the intima of the blood vessel wall, the drug is rapidly released and transferred in the local blood vessel wall. In order to prevent vascular restenosis after vascular intervention, the drug coating on the existing drug balloon mostly uses polymer as the carrier. Due to the large size of the polymer carrier, the saturation of the drug on the balloon and the drug delivery area are relatively small. Therefore, when the drug is applied to the blood vessel wall, the balloon needs to be expanded several times, which increases the difficulty and time of the operation, and because the drug balloon moves to the lesion in the blood vessel, the flow of blood will The drug coating on the surface of the balloon "washes away" part, so the current drug coating on the balloon is generally thicker, there is a possibility of side effects due to a large amount of drug, and the problem of waste due to low bioavailability of the drug, so it is urgent to design A drug balloon catheter and a surface treatment method for the drug balloon

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