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Traditional Chinese medicine composition for treating hashimoto thyroiditis and preparation method thereof

A technology of Hashimoto's thyroiditis and composition, which is applied in the field of traditional Chinese medicine composition and its preparation for the treatment of Hashimoto's thyroiditis, which can solve the problems of limited clinical application, lack of standardization, and easy recurrence of side effects, and achieve the improvement of thyroid secretion Function, broad clinical application prospect, good therapeutic effect

Active Publication Date: 2022-03-29
ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, Western medicine mostly uses thyroid hormone injections. Although the initial stage can obviously improve the patient's physical condition, as the disease progresses, the patient's dependence on hormones increases, and the required dosage will gradually increase to become ineffective, accompanied by adverse phenomena. , easy to relapse after drug withdrawal until hypothyroidism
As an adjuvant therapy for Hashimoto's disease, selenium is not widely used in clinical treatment, and its side effects greatly limit its clinical application
However, the use of glucocorticoids for immunomodulatory therapy also has the problem of large side effects, and there are still controversies about how to use them rationally, and there is a lack of certain standardization in clinical practice.

Method used

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  • Traditional Chinese medicine composition for treating hashimoto thyroiditis and preparation method thereof
  • Traditional Chinese medicine composition for treating hashimoto thyroiditis and preparation method thereof
  • Traditional Chinese medicine composition for treating hashimoto thyroiditis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation of embodiment 1 mixture

[0053] Astragalus 0.3kg Atractylodes macrocephala 0.3kg Poria cocos 0.2kg

[0054] Polyporus 0.1kg Coix seed 0.2kg Psoralen 0.1kg

[0055] Mulberry 0.2kg Lycium barbarum 0.1kg Curculigo 0.2kg

[0056] A. Take 9 raw medicinal materials of Radix Astragali, Atractylodes macrocephala, Poria cocos, Polyporus polyporus, coix seed, psoralen, mulberry, medlar and curculigo, cleanly select, and coarsely crush them respectively to obtain coarse granules of the raw materials, which are set aside;

[0057] B. Weigh the coarse grains of raw medicinal materials in step A according to the prescription, mix well, add water to decoct twice, add 10 times the amount of water for the first time, decoct for 2 hours, add 8 times the amount of water for the second time, decoct for 1.5 hours, The decoction liquids were combined, filtered, concentrated under reduced pressure to an extract with a relative density of 1.10 at 50-60°C, and set aside;

[...

Embodiment 2

[0060] The preparation of embodiment 2 oral liquid

[0061] Astragalus 0.1kg Atractylodes macrocephala 0.1kg Poria cocos 0.1kg

[0062] Polyporus 0.2kg Coix seed 0.4kg Psoralen 0.2kg

[0063] Mulberry 0.1kg Lycium barbarum 0.2kg Curculigo 0.05kg

[0064] A. Take 9 raw medicinal materials of Radix Astragali, Atractylodes macrocephala, Poria cocos, Polyporus polyporus, coix seed, psoralen, mulberry, medlar and curculigo, cleanly select, and coarsely crush them respectively to obtain coarse granules of the raw materials, which are set aside;

[0065] B. Weigh the coarse grains of raw medicinal materials in step A according to the prescription amount, mix well, add water to decoct twice, add 10 times the amount of water for the first time, decoct for 3 hours, add 8 times the amount of water for the second time, decoct for 1 hour, and decoct Combine the boiled liquids, filter, concentrate under reduced pressure to an extract with a relative density of 1.15 at 50-60°C, and set asi...

Embodiment 3

[0068] The preparation of embodiment 3 granules

[0069] Astragalus 0.15kg Bran fried Atractylodes macrocephala 0.15kg Poria cocos 0.12kg

[0070] Polyporus 0.12kg Stir-fried coix seed with bran 0.3kg Psoralen 0.12kg

[0071] Mulberry 0.12kg Goji 0.12kg Curculigo 0.09kg

[0072] A. Take 9 raw medicinal materials of Radix Astragali, Atractylodes macrocephala, Poria cocos, Polyporus polyporus, coix seed, psoralen, mulberry, medlar and curculigo, cleanly select, and coarsely crush them respectively to obtain coarse granules of the raw materials, which are set aside;

[0073] B. Weigh the coarse grains of raw medicinal materials in step A according to the prescription amount, mix well, add water to decoct twice, add 8 times the amount of water for the first time, decoct for 3 hours, add 6 times the amount of water for the second time, decoct for 2 hours, and decoct Combine the boiled liquids, filter, concentrate under reduced pressure to an extract with a relative density of 1.1...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating hashimoto thyroiditis and a preparation method thereof. The traditional Chinese medicine composition is prepared from nine raw medicinal materials including radix astragali, rhizoma atractylodis macrocephalae, poria cocos, polyporus umbellatus, semen coicis, fructus psoraleae, herba taxilli, fructus lycii and rhizoma curculiginis, the medicine property is mild, the compatibility is precise and appropriate, the synergistic effect is achieved, and the traditional Chinese medicine composition can tonify qi, strengthen superficies, invigorate the spleen and tonify Pharmacodynamic experiments show that the composition can significantly reduce the levels of serum inflammatory cytokines IL-6 and IL-12 and the levels of serum thyroid autoantibodies TGAb and TPOAb of rats suffering from hashimoto thyroiditis, significantly improves the secretion function of thyroid, has a good treatment effect on hashimoto thyroiditis, and has good clinical application prospects. The traditional Chinese medicine composition has an exact curative effect on hypothyroidism caused by hashimoto thyroiditis, and has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating Hashimoto's thyroiditis and a preparation method thereof. Background technique [0002] Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis and lymphoid goiter, is a common thyroid autoimmune disease, and its pathological feature is that lymphocytes and plasma cells in the thyroid are diffusely Sexual infiltration, destruction of thyroid follicles, and new capillaries in the glandular tissue eventually lead to hypothyroidism. The clinical features are normal thyroid function, hyperthyroidism (hyperthyroidism) or hypothyroidism (hypothyroidism). At present, the incidence of Hashimoto's thyroiditis is increasing year by year, and it is more common in women aged 30 to 50. The onset is insidious, the de...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P37/02
CPCA61K36/481A61K36/284A61K36/076A61K36/07A61K36/8994A61K36/487A61K36/185A61K36/815A61K36/88A61K9/0053A61P37/02A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00Y02A50/30
Inventor 葛明华郑传铭李清林黄萍张轶雯王佳峰蒋烈浩
Owner ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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