Preparation method of 4-benzyloxy phenyl ethyl n-decanoate

Abstract

The invention discloses a preparation method of 4-benzyloxy phenyl ethyl n-decanoate, which comprises the following steps: A, adding methanol, p-hydroxyphenethyl alcohol and equivalent benzyl chloride into a clean three-neck flask, uniformly stirring and mixing, then adding sodium hydroxide solid in three batches, heating to reflux after each time of addition, and reacting for 0.5 hour, so as to obtain 4-benzyloxy phenyl ethyl n-decanoate; b, after the reaction is finished, directly distilling out the solvent, then after the solvent is completely distilled, directly dropwise adding n-decanoyl chloride with the same equivalent amount, and controlling the temperature to be lower than 20 DEG C, C, after the reaction is finished, adding a large amount of water, separating out a large amount of product at the moment, uniformly stirring, and centrifuging to obtain a crude product; and D, adding ethanol into the crude product, heating and dissolving, cooling and separating out, and centrifuging again to obtain a refined product 4-benzyloxy phenyl ethyl n-decanoate. In the reaction stage, the usage amount of solvents and reagents is reduced, no acid-binding agent is used, and therefore pollution to the environment is reduced, no by-product exists in the reaction process, and the production process is more environmentally friendly.

Description

technical field [0001] The invention relates to the technical field of biochemical industry, in particular to a preparation method of 4-benzyloxyphenylethyl n-decanoate. Background technique [0002] 4-Benzyloxyphenylethyl n-decanoate is a thermochromic additive, which is usually obtained by reacting 4-benzyloxyphenylethyl alcohol with n-decanoyl chloride, but the reaction is very slow, and it is easy to blunt after a certain degree of reaction. Therefore, it needs to be improved. There are few reports on the direct esterification of 4-benzyloxyphenylethanol and n-decanoic acid under acid catalysis, but 4-benzyloxyphenylethanol is easy under the condition of higher temperature under acid catalysis. Dehydration causes side reactions, resulting in reduced yield and impure product. The existing 4-benzyloxyphenylethyl n-decanoate preparation process has a long reaction route, cumbersome methods, and many by-products, resulting in low product yield. , Poor production efficiency ...

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Problems solved by technology

[0002] 4-Benzyloxyphenylethyl n-decanoate is a thermochromic additive, which is usually obtained by reacting 4-benzyloxyphenylethyl alcohol with n-decanoyl chloride, but the reaction is very slow, and it is easy to blunt after a certain degree of reaction. Therefore, it needs to be improved. There are few reports on the direct esterification of 4-benzyloxyphenylethanol and n-decanoic acid under acid catalysis, but 4-benzyloxyphenylethanol is easy under the condition of higher temperature under acid catalysis. Dehydration causes side reactions to occur, resulting in reduced yield and impure product. The existing 4-benzyloxyphenylethyl n-decanoate preparation process has a long reaction route, cumbersome methods, and many by-products, resulting in low product yield. , poor production efficiency and other issues

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