Two-component paste, application and preparation method of bone cement

Abstract

The invention discloses a double-component paste. The double-component paste comprises a pasty component A and a pasty component B, the pasty component A comprises the following components in percentage by mass: 65-85% of PMMA (Polymethyl Methacrylate) polymer powder A; 1-5% of a surfactant; 10-30% of a solvent; 0.5-2.5% of a dispersant; 0-5% of antibiotics; wherein an initiator is wrapped in the PMMA polymer powder A, and the content of the initiator accounts for 1-10% of the content of the PMMA polymer powder A; the pasty component B comprises the following components in percentage by mass: 20-60% of PMMA (Polymethyl Methacrylate) polymer powder B; 0.1 to 1.5 percent of an auxiliary agent; 7-30% of a methacrylate monomer; 0.05%-0.5% of an accelerant; 0.001%-0.005% of a polymerization inhibitor; and 30%-50% of a developing agent. The invention also provides an application of the two-component paste and a preparation method of the bone cement. The two-component paste can be taken at any time, bone cement is formed when the two-component paste is taken, the service life of the bone cement is prolonged, the bonding effect of the bone cement is improved, meanwhile, the two-component paste has a photothermal effect, and peripheral tumor cells can be killed under infrared illumination.

Description

technical field [0001] The invention belongs to the technical field of bone cement, and relates to a two-component paste, its application and a preparation method of bone cement. Background technique [0002] With the development of society, osteoporosis and osteoporotic fractures have become public health issues of worldwide concern. In orthopedic surgery, percutaneous vertebroplasty has become a minimally invasive treatment method for metastatic vertebral tumors, primary vertebral tumors, and vertebral compression fractures caused by osteoporosis. Puncture into the vertebral body to inject bone cement to strengthen the vertebral body to achieve the purpose of treatment. PMMA bone cement is currently the most clinically used bone cement, which consists of powder and liquid. The main component of the powder is polymethyl methacrylate PMMA, and the main component of the liquid is methyl methacrylate, that is, MMA monomer. For the existing PMMA bone cement technology, users...

AI Technical Summary

Problems solved by technology

The bone cement is composed of two paste components A and B, whereby paste component A contains the accelerator and paste component B contains the initiator and has an appropriate composition to make it storage stable at room temperature , but its paste component B is a simple initiator, the initiation rate is too fast after mixing, the reaction is fast, and it is easy to mix unevenly with the powder, which is not conducive to the stable use of bone cement

Patent document CN103566416B discloses a preparation method of cheaper raw materials in the existing paste bone cement technology, but still can ensure the processability of the existing bone cement paste, but its components are not sticky within 15 minutes after mixing, Cannot enter the application period

Patent document CN104353117A discloses a bone cement that subsequently generates heat, adding gold nanorods to the bone cement, and using the photothermal effect of gold nanorods to kill surrounding tumor cells, but it is in the traditional bone cement formula powder The introduction of gold nanorods, the uniformity of gold nanorods in the powder is poor and the application time of bone cement is relatively limited

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