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Plasma kallikrein inhibitor

An independent and selected technology, applied in anti-inflammatory agents, blood diseases, non-central analgesics, etc., which can solve problems such as poor chemical stability and potential toxicity

Pending Publication Date: 2022-03-18
KALVISTA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is well known that prodrugs may have several disadvantages such as poor chemical stability and potential toxicity from inert carriers or from unexpected metabolites

Method used

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  • Plasma kallikrein inhibitor
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Examples

Experimental program
Comparison scheme
Effect test

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Abstract

The present invention provides compounds of formula (I); compositions comprising such compounds; the use of such compounds in therapy (e.g., in the treatment or prevention of diseases or conditions involving plasma kallikins activity); and methods of treating patients using such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

Description

technical field [0001] The present invention relates to enzyme inhibitors as inhibitors of plasma kallikrein, and to pharmaceutical compositions and uses of such inhibitors. Background technique [0002] The heterocyclic derivatives of the present invention are inhibitors of plasma kallikrein and have various therapeutic applications, especially in bradykinin-mediated angioedema hereditary angioedema and bradykinin-mediated non-hereditary angioedema In the treatment of acute edema (BK-AEnH). [0003] Plasma kallikrein is a trypsin-like serine protease that releases kinins from kininogens (see K.D. Bhoola et al., "Kallikrein-Kinin Cascade", Encyclopedia of Respiratory Medicine, pp. 483-493; J.W. Bryant et al. , "Human plasma kallikrein-kinin system: physiological and biochemical parameters" Cardiovascular and haematological agents in medicinal chemistry, 7, pp. 234-250, 2009; K.D. Bhoola et al., Pharmacological Rev., 1992, 44, 1; and D.J.Campbell, "Towards understanding the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/14C07D403/14C07D405/14C07D413/14C07D417/14C07D471/04A61P29/00C07D487/04C07D487/08C07D491/107C07D491/147C07D491/20C07D513/04A61K31/4725
CPCC07D401/14C07D405/14C07D403/14C07D487/04C07D471/04C07D491/107C07D491/20C07D491/147C07D413/14C07D513/04C07D417/14C07D487/08A61P29/00A61K31/55A61K31/4725A61P7/10
Inventor 丽贝卡·路易丝·戴维汉娜·乔伊·爱德华兹戴维·米歇尔·埃万斯西蒙·泰亚比·霍奇森亚历山大·马扎卡尼迈克尔·约翰·斯托克斯托马斯·马休·贝克马休·罗伯特·康罗伊阿伦·约翰·史密斯戴维·爱德华·克拉克
Owner KALVISTA PHARMA
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