Plasma kallikrein inhibitor
An independent and selected technology, applied in anti-inflammatory agents, blood diseases, non-central analgesics, etc., which can solve problems such as poor chemical stability and potential toxicity
Pending Publication Date: 2022-03-18
KALVISTA PHARMA
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Problems solved by technology
However, it is well known that prodrugs may have several disadvantages such as poor chemical stability and potential toxicity from inert carriers or from unexpected metabolites
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Abstract
The present invention provides compounds of formula (I); compositions comprising such compounds; the use of such compounds in therapy (e.g., in the treatment or prevention of diseases or conditions involving plasma kallikins activity); and methods of treating patients using such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
Description
technical field [0001] The present invention relates to enzyme inhibitors as inhibitors of plasma kallikrein, and to pharmaceutical compositions and uses of such inhibitors. Background technique [0002] The heterocyclic derivatives of the present invention are inhibitors of plasma kallikrein and have various therapeutic applications, especially in bradykinin-mediated angioedema hereditary angioedema and bradykinin-mediated non-hereditary angioedema In the treatment of acute edema (BK-AEnH). [0003] Plasma kallikrein is a trypsin-like serine protease that releases kinins from kininogens (see K.D. Bhoola et al., "Kallikrein-Kinin Cascade", Encyclopedia of Respiratory Medicine, pp. 483-493; J.W. Bryant et al. , "Human plasma kallikrein-kinin system: physiological and biochemical parameters" Cardiovascular and haematological agents in medicinal chemistry, 7, pp. 234-250, 2009; K.D. Bhoola et al., Pharmacological Rev., 1992, 44, 1; and D.J.Campbell, "Towards understanding the...
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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/14C07D403/14C07D405/14C07D413/14C07D417/14C07D471/04A61P29/00C07D487/04C07D487/08C07D491/107C07D491/147C07D491/20C07D513/04A61K31/4725
CPCC07D401/14C07D405/14C07D403/14C07D487/04C07D471/04C07D491/107C07D491/20C07D491/147C07D413/14C07D513/04C07D417/14C07D487/08A61P29/00A61K31/55A61K31/4725A61P7/10
Inventor 丽贝卡·路易丝·戴维汉娜·乔伊·爱德华兹戴维·米歇尔·埃万斯西蒙·泰亚比·霍奇森亚历山大·马扎卡尼迈克尔·约翰·斯托克斯托马斯·马休·贝克马休·罗伯特·康罗伊阿伦·约翰·史密斯戴维·爱德华·克拉克
Owner KALVISTA PHARMA
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