Novel marker for judging malignant tumor of cholangiocarcinoma and application of novel marker

Abstract

The invention belongs to the technical field of biology, and discloses a novel marker for judging a malignant tumor of bile duct cancer, and the novel marker for judging the malignant tumor of bile duct cancer is Gankyrin. According to the novel marker for judging the malignant tumor of the cholangiocarcinoma, provided by the invention, the expression of the Gankyrin in human CCA tissues and cell lines is evaluated, and the influence of the Gankyrin on the growth and metastasis of the CCA is detected in vivo and in vitro respectively. The invention finds that the Gankyrin can be used as an important prognostic marker of the CCA, and meanwhile, the Gankyrin has important enlightenment for the treatment of the CCA in the future by exploring the action mechanism of the Gankyrin. The invention finds that the Gankyrin has important significance for evaluating the prognosis of the CCA, activates an IL-6 / STAT3 signal channel by down-regulating an Rb protein, plays a key role in the generation and the metastasis of the CCA, and can be used for carrying out targeted therapy aiming at the important way which influences the generation and the metastasis of the CCA in the future.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a novel marker for judging the malignant tumor of cholangiocarcinoma and its application. Background technique [0002] At present, cholangiocarcinoma (CCA) is a kind of malignant tumor with high degree of malignancy, complex anatomical structure, and indistinct clinical manifestations in the early stage. When CCA is diagnosed, most of them are in the middle and advanced stage of the disease. At this time, the curative rate of surgery is low, and it is not sensitive to radiotherapy and chemotherapy, and the prognosis is poor. The 5-year survival rate of untreated cholangiocarcinoma patients is only 5% to 10%. However, there is no report on the markers leading to the ability of CCA cells to acquire invasion and metastasis in the prior art. Therefore, it is an urgent problem to find the molecules that cause CCA cells to acquire the ability to invade and metastasize, use th...

AI Technical Summary

Problems solved by technology

[0003] Through the above analysis, the existing problems and defects of the prior art are as follows: the markers that cause CCA cells to acquire the ability to invade and metastasize have not been reported in the prior art, and there is a lack of such a marker for judging the prognosis of cholangiocarcinoma

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