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Method for preparing chrysanthemum new section I and chrysanthemum new section J from stems and leaves of Huai chrysanthemum and application of chrysanthemum new section I and chrysanthemum new section J

A chrysanthemum, stem and leaf technology, applied in the field of medicine, can solve problems such as no public reports, and achieve the effects of improving cell degranulation, abundant raw materials, and significant economic and social benefits

Pending Publication Date: 2022-03-01
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on the principles of "green development" and "resource conservation", the present invention separates and identifies two terpenoid compounds from Huai chrysanthemum, chrysanthemum new tie I and chrysanthemum new tie J, and the experimental results show that these two compounds can inhibit β -The release of hexosaminidase can improve the degranulation phenomenon of RBL-2H3 cells, suggesting that Juhuaxintie I and Juhuaxintie J may play an anti-asthma effect by inhibiting mast cell degranulation, but there is no public report so far

Method used

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  • Method for preparing chrysanthemum new section I and chrysanthemum new section J from stems and leaves of Huai chrysanthemum and application of chrysanthemum new section I and chrysanthemum new section J
  • Method for preparing chrysanthemum new section I and chrysanthemum new section J from stems and leaves of Huai chrysanthemum and application of chrysanthemum new section I and chrysanthemum new section J
  • Method for preparing chrysanthemum new section I and chrysanthemum new section J from stems and leaves of Huai chrysanthemum and application of chrysanthemum new section I and chrysanthemum new section J

Examples

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Effect test

Embodiment 1

[0034]A kind of preparation method of the present invention prepares chrysanthemum new tie I and chrysanthemum new tie J from the stem and leaf of chrysanthemum chrysanthemum, comprises the following steps: 35kg of stem and leaf of chrysanthemum chrysanthemum is broken through tissue, extracts 2 times with volume concentration 50% acetone aqueous solution, The dosage of acetone aqueous solution is 9 times of the weight and volume of the stem and leaf of Huai chrysanthemum. The weight and volume refer to the solid in kg and the liquid in L. Dispersed and dissolved in water to obtain a dispersion, sequentially extracted with petroleum ether, ethyl acetate, and n-butanol equal to the volume of the dispersion, respectively collecting the extracts, recovering petroleum ether, ethyl acetate, and n-butanol under reduced pressure, to obtain petroleum ether part, ethyl acetate part, n-butanol part and water part; the n-butanol part was dissolved in water, subjected to polyamide column c...

Embodiment 2

[0037] A kind of preparation method of the present invention prepares chrysanthemum new tie I and chrysanthemum new tie J from the stem and leaf of chrysanthemum chrysanthemum, comprises the following steps: 33kg of stem and leaf of chrysanthemum chrysanthemum is broken through tissue, extracts twice with 50% acetone aqueous solution of volume concentration, The dosage of acetone aqueous solution is 8 times of the weight and volume of the stems and leaves of Huai chrysanthemum, and the weight and volume refer to the solid in kg and the liquid in L. Dispersed and dissolved in water to obtain a dispersion, sequentially extracted with petroleum ether, ethyl acetate, and n-butanol equal to the volume of the dispersion, respectively collecting the extracts, recovering petroleum ether, ethyl acetate, and n-butanol under reduced pressure, to obtain petroleum ether part, ethyl acetate part, n-butanol part and water part; the n-butanol part was dissolved in water, subjected to polyamide...

Embodiment 3

[0040] A kind of preparation method of the present invention prepares chrysanthemum new tie I and chrysanthemum new tie J from the stem and leaf of chrysanthemum chrysanthemum, comprising the following steps: 33-37 kg of the stem and leaf of chrysanthemum chrysanthemum are broken through tissue, and extracted with 50% acetone aqueous solution of volume concentration 2 Time, each consumption of acetone aqueous solution is 8-10 times of the weight volume of chrysanthemum chrysanthemum stem and leaf, and weight volume refers to solid in kg, liquid in L, and the extract is concentrated under reduced pressure to obtain 2.6-3.0 kg of total extract. Disperse and dissolve the extract with 4-5 times the weight and volume of water to obtain a dispersion, which is extracted with petroleum ether, ethyl acetate, and n-butanol in the same volume as the dispersion, and the extracts are collected respectively, and petroleum ether and ethyl acetate are recovered under reduced pressure. , n-buta...

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Abstract

The invention relates to a method for preparing chrysanthemum Xinjiang I and chrysanthemum Xinjiang J from stems and leaves of Huai Chrysanthemum and application of the chrysanthemum Xinjiang I and chrysanthemum Xinjiang J, which can effectively solve the problem of extracting new compounds from the stems and leaves of Huai Chrysanthemum to effectively prepare anti-asthma drugs, and the chrysanthemum Xinjiang I and chrysanthemum Xinjiang J inhibit the release of beta-hexosaminidase, improve the RBL-2H3 cell degranulation phenomenon and improve the anti-asthma effect. The Huai chrysanthemum stem leaves are effectively used for preparing the anti-asthma medicine, the medicinal value and commercial value of the Huai chrysanthemum stem leaves are developed, the Huai chrysanthemum stem leaves are innovated in the aspect of the asthma treatment medicine, raw materials are rich, the preparation method is easy to operate, no pollution is caused to the environment, resources are saved, and remarkable economic and social benefits are achieved.

Description

technical field [0001] The present invention relates to medicine, particularly a kind of method and application thereof of preparing chrysanthemum new tie I and chrysanthemum new tie J from stem and leaf of chrysanthemum chrysanthemum. Background technique [0002] Chrysanthemum (Chrysanthemum morifolium Ramat.) is the dry flower head of Chrysanthemum, a plant of Compositae. It is sweet and bitter in taste, slightly cold in nature, and mainly returns to the lung and liver meridian. As a traditional Chinese herbal medicine, chrysanthemum is widely distributed and has high medicinal value. Chrysanthemum has good effects in medicine and health care. It is the first batch of medicinal and edible materials issued by the Ministry of Health of my country. The 2020 edition of "Chinese Pharmacopoeia" includes "Huaiju", "Boju", "Chuju", "Gongju", and "Hangju" as "chrysanthemum" as medicine, which fully affirms the medicinal value of Huaiju. At present, there are many researches on ...

Claims

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Application Information

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IPC IPC(8): C07C51/47C07C51/48C07C59/46C07C45/79C07C45/80C07C49/743A61P11/06
CPCC07C51/47C07C51/48C07C45/79C07C45/80A61P11/06C07C2602/28C07C2601/14C07C59/46C07C49/743
Inventor 李孟曾梦楠石静亚王小兰张靖柯贾菊芳张博文冯卫生
Owner HENAN UNIV OF CHINESE MEDICINE
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