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Bioenergetic combinations and methods of using same

A technology of composition and energy efficiency, which can be used in pharmaceutical formulations, cosmetic preparations, preparations for skin care, etc., and can solve problems such as the undisclosed mitochondrial fragmentation mechanism

Pending Publication Date: 2022-02-25
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] None of the above additional information discloses the mechanism of mitochondrial fragmentation

Method used

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  • Bioenergetic combinations and methods of using same
  • Bioenergetic combinations and methods of using same
  • Bioenergetic combinations and methods of using same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0127]Example 1. Mitochondrial Fragmentation in Keratinocytes

[0128] The purpose of this experiment was to compare the degree of skin protection delivered by different active substances against mitochondrial fragmentation that occurs due to aging.

[0129] The higher the value of mitochondrial fragmentation, the less skin protection delivered by a given active or combination of actives. Note that for biological systems such as mitochondria, which are the microscale components of skin cells, the absolute values ​​of the numbers for mitochondrial fragmentation are small, and small differences can be significant.

[0130] The table below shows the effect of B3 alone and in combination with low levels of AceMet and MeNAM on mitochondrial fragmentation in keratinocytes after 5 days of exposure:

[0131] Table 1

[0132] testing sample mitochondrial fragmentation Control group (no treatment) 1.88 B3*(10mM) 1.67 a

AceMet*(500uM)+B3(10mM) 1.59 a,b ...

Embodiment 2

[0138] Example 2. Mitochondrial Fragmentation in Keratinocytes - UV Study

[0139] The aim of this experiment was to compare the degree of skin protection delivered by different active substances against mitochondrial fragmentation that occurs due to aging with and without UV exposure.

[0140] The table below shows the effect of B3 and low levels of AceMet and MeNAM on mitochondrial fragmentation in keratinocytes before and after 3 days of UV exposure:

[0141] Table 2

[0142]

[0143] a Significantly better than the control group without UV exposure (P< / =0.05)

[0144] b Significantly better than B3 alone (P< / =0.05)

[0145] c Significantly worse than the control group without UV exposure (P< / =0.05)

[0146] d Significantly better than the control group exposed to UV (P< / =0.05)

[0147] e Significantly worse than B3 (P< / =0.05)

[0148] f Significantly better than AceMet alone (P< / =0.05)

[0149] g Significantly better than MeNAM alone (P< / =0.05)

[0150] h...

Embodiment 3

[0154] Personal care formulations according to the present invention are shown in the table below. All values ​​in the tables represent % by weight in the composition.

[0155] Table 3A - Oil-in-water formulations, lotions and creams

[0156] OW-1 OW-2 OW-3 OW-4 OW-5 water to 100 to 100 to 100 to 100 to 100 glycerin 0-40 1-40 1-5 1-10 1-40 Propylene Glycol 0-5 0-5 Butanediol 0-5 0-5 0-5 carbomer 0-2 0.03-1 Ammonium Acryloyldimethyltaurate / VP Copolymer 0-1 0.03-1 0.01-1 Styrene / Acrylate Copolymer 0-1 0.01-1 xanthan gum 0-1 0.01-1 EDTA 0.01-0.01 0.01-0.01 0.01-1 0.01-1 0.01-1 preservative 0.02-2 0.02-2 0.02-2 0.02-2 0.02-2 Titanium oxide 0-10 0.01-10 0.01-10 0.01-10 0.01-10 Colorant / Pigment 0-5 0-5 0-5 0-5 0-5 Triethanolamine / Sodium Hydroxide / Potassium Hydroxide 0-3 0.01-3 0.01-3 0.01-3 0.01-3 stearic acid ...

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Abstract

Topical personal care compositions for improving cellular energy efficiency by protecting skin from mitochondrial fragmentation that takes place in the cells of an aging individual in need thereof. Use of a topical personal care composition comprising niacinamide and of one or more cooperative skin benefit agents for reducing cellular mitochondrial fragmentation, which cooperative agents are selected from the group consisting of 1-methylnicotinamide chloride, N-acetylmethionine, mixtures thereof, and derivatives thereof. Use of niacinamide and cooperative skin benefit agent selected from 1-methylnicotinamide chloride, N-acetylmethionine, mixtures thereof, and derivatives thereof in the manufacture of a topical personal care composition for decreasing or preventing mitochondrial fragmentation in skin cells and for increasing skin cellular energy.

Description

technical field [0001] The present invention relates to a combination of niacinamide and one or more synergistic skin benefit agents for preventing mitochondrial fragmentation in skin cells and increasing skin cell energy or skin bioenergy. Background technique [0002] High energy is often associated with desirable attributes such as vitality, health, and youth. It is less obvious whether or how high energy or related properties are achieved, especially if or how they are achieved at the cellular level. [0003] While there is much literature on the energy cycle of cell metabolism, the technology of harnessing the functional components of cells to achieve or look youthful remains uncertain. While this is true in all cells of the body, whether or how the cellular energy metabolism cycle or its manipulation can achieve youthful-looking skin is especially unpredictable. [0004] In human cells, the three major energy-generating cellular processes are glycolysis (G), the tric...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/60A61Q19/08A61K8/46
CPCA61K8/46A61K8/675A61Q19/08
Inventor S·A·罗查C-Y·江J·G·罗萨J·C-S·聂
Owner UNILEVER IP HLDG BV
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