Pharmaceutical composition for improving sleep and preparation method and application thereof

A technology for improving sleep and composition, applied in the field of pharmaceutical composition for improving sleep and its preparation, can solve problems such as side effects, drug dependence, etc., achieve the effect of precise formula, no toxic side effects, and improving mouse sleep

Pending Publication Date: 2022-02-22
成都仁青益寿药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking sleeping pills can temporarily relieve the trouble of insomnia, but long-term use will not only cause side effects, but also cause drug dependence

Method used

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  • Pharmaceutical composition for improving sleep and preparation method and application thereof
  • Pharmaceutical composition for improving sleep and preparation method and application thereof
  • Pharmaceutical composition for improving sleep and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1, Preparation of a pharmaceutical composition of the present invention

[0032] Prescription: 30g of floating wheat, jujube 15g, licorice 10g, sour jujube rin 20g, gardenia 10g, eater 豉 10g.

[0033] Preparation method: It is weighed with each of the above-mentioned preparations, adding water extraction twice, plus 10 times weight of water each time, each extraction for 2 h. After the extraction is completed, the extract is concentrated to obtain a drug composition to concentrate the extract.

[0034] The concentrated dipper obtained in this example can be used to prepare a dosage form of a paste, oral liquid, a granule, a tablet, a capsule; the powder obtained by spraying the extract is used to prepare a granule, tablet, capsule and other dosage forms. .

Embodiment 2

[0035] Example 2, Preparation of a pharmaceutical composition of the present invention

[0036] Prescription: 28g of floating wheat, jujube 13g, licorice 8g, sour jujube 18g, gardenia 8g, palery 豉 8g.

[0037] Preparation method: in Example 1.

Embodiment 3

[0038] Example 3, Preparation of a pharmaceutical composition of the present invention

[0039] Prescription: 32g of floating wheat, jujube 17g, licorice 12g, sour jujube Rell 22g, gardenia 12g, palery 12g.

[0040] Preparation method: in Example 1.

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Abstract

The invention relates to a pharmaceutical composition for improving sleep and a preparation method and application thereof. The pharmaceutical composition for improving sleep comprises the following raw material medicines in parts by weight: 25-35 parts of blighted wheat, 10-20 parts of Chinese dates, 8-12 parts of liquorice, 15-25 parts of spina date seeds, 8-12 parts of cape jasmine and 8-12 parts of fermented soybeans. Experimental results prove that the pharmaceutical composition provided by the invention is precise and appropriate in formula, can remarkably prolong the pentobarbital sodium induced sleep time of mice, increase the sleep incidence rate induced by the subthreshold dosage of pentobarbital sodium and shorten the sleep latency period induced by pentobarbital sodium of the mice, and has an excellent effect on improving the sleep of the mice; the pharmaceutical composition is good in safety, free of toxic and side effects, convenient to use and wide in application prospect in preparation of drugs for improving sleep.

Description

Technical field [0001] The present invention is the field of traditional Chinese medicine compositions, and more particularly to a pharmaceutical composition which improves sleep and its preparation methods and applications. Background technique [0002] It is also called insomnia, which is mainly due to clinical syndrome characterized by normal sleep, mainly as the lack of sleep time and depth. It is difficult to fall asleep, or you can't sleep, you wake up, or you will be more difficult to sleep again; the heavy side is turning back, the night is not in the night, or a series of symptoms such as a nightmare. With the acceleration of social life and work rhythm, the incidence of insomnia has risen, giving more negative impact on the physical and mental health of patients. [0003] Insomnia will cause a mentally endless, slow response, physical fatigue, and even upset, seriously affect physical and mental health and work, study and life, long-term insomnia will cause intelligent ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P25/20
CPCA61K36/899A61K36/725A61K36/484A61K36/744A61K36/48A61P25/20A61K2300/00
Inventor 徐亮何仲清朱志刘洋俸世洪黄浩陶冬祝世凡
Owner 成都仁青益寿药业有限公司
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