Application of Futashu mitoxantrone hydrochloride injection for tracing as fluorescent tracer and fluorescent camera device applied to mitoxantrone hydrochloride injection

Abstract

The invention relates to the technical field of lymphatic fluorescence tracing, in particular to application of a Futashu mitoxantrone hydrochloride injection for tracing as a fluorescence tracer and a fluorescence camera device for the mitoxantrone hydrochloride injection. The Futashu mitoxantrone hydrochloride injection for tracing is mixed with serum of mammals, and then a sphere-like biological self-assembled nanocrystal with a smooth surface is formed through non-covalent interaction, wherein the particle size of the nanocrystal is about 100 nm, and the nanocrystal to has a fluorescence spectrum characteristic, and generates fluorescence with a wavelength of 710-810 nm under the irradiation of light with a wavelength of 600-710 nm. The fluorescence camera device is used for fluorescence tracing imaging of the Futashu mitoxantrone hydrochloride injection for tracing. Fluorescence generated by excitation of the Futashu nanocrystal has very good penetrability relative to biological tissues, so the defects of a traditional fluorescent tracer agent are effectively overcome, and the Futashu nanocrystal can become a new generation of lymphatic fluorescent tracer medicine.

Description

technical field [0001] The invention relates to the technical field of lymphatic fluorescent tracing, in particular to the application of mitoxantrone hydrochloride injection for futashu tracing as a fluorescent tracer and a fluorescent imaging device used therefor. Background technique [0002] Biopsy or lymphatic dissection of sentinel lymph nodes to determine the location and extent of lymphatic dissection is a very important link in malignant tumor surgery. In lymphatic tracing technology, medical clinical methods mainly include fluorescent tracing method and dye method. [0003] The fluorescent tracer method adopts the emerging fluorescence detection technology, which has been used in medical treatment for more than 10 years. Although many substances can produce fluorescence, not all substances that can produce fluorescence can be used as Medical fluorescent tracers. At present, there are only four drugs known to have fluorescent spectral properties for clinical use: ...

AI Technical Summary

Problems solved by technology

[0004] Methylene blue is highly irritating to the human body, and it is clearly stipulated in the Pharmacopoeia that it cannot be used for subcutaneous injection, thus limiting the clinical application of the drug; indocyanine green is a strong fluorescent substance. If it is damaged, indocyanine green will flow out along with the lymph fluid and diffuse on the wound surface, causing fluorescent pollution, making it difficult to distinguish lymphatic vessels and lymph nodes. Doctors need to have extremely high skills to avoid the occurrence of fluorescent pollution

[0005] The tracers commonly used in the dye method mainly include methylene blue and nano-carbon, both of which have their own defects when they are applied to lymphography: methylene blue is highly irritating to the human body, so it must be used for sentinel lymph detection in the operation. Excision of the dyed area, limited indications; nano-carbon is a black dye, which is difficult to be metabolized in the human body, and has a greater impact on patients undergoing secondary surgery

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