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Application of cinnamyl aldehyde combined with ceftriaxone sodium

A technology of ceftriaxone sodium and cinnamaldehyde, which is applied in the direction of medical preparations containing active ingredients, drug combinations, active ingredients of aldehydes, etc., to achieve the effects of reducing dosage, preventing bacterial intestinal colonization, and improving intestinal inflammation

Pending Publication Date: 2021-12-31
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, there have not been any reports and studies on the combination of cinnamaldehyde and antibiotics against drug-resistant Salmonella

Method used

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  • Application of cinnamyl aldehyde combined with ceftriaxone sodium
  • Application of cinnamyl aldehyde combined with ceftriaxone sodium
  • Application of cinnamyl aldehyde combined with ceftriaxone sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Effect of cinnamaldehyde combined with ceftriaxone sodium on inhibiting drug-resistant Salmonella in vitro

[0035] 1. Determination of minimum inhibitory concentration (MIC): The MICs of cinnamaldehyde and ceftriaxone against drug-resistant Salmonella were respectively determined by micro broth dilution method. The specific operation method is as follows: Add broth medium to the 96-well plate, 200 μL in the first well of row A-E, and 100 μL in each well, add the prepared drug solution (40.96 mg / mL) to each well in the first row , through the doubling dilution method, the final mass concentration of the drug is 1024, 512, 256, 128, 64, 32, 16, 8, 4, 2 μg / mL, and then add the bacteria solution of drug-resistant Salmonella cultured in advance to each well , the bacterial solution concentration is 10^5CFU / mL. In addition, only culture medium and bacterial suspension were added to the positive control group, only culture medium and drugs were added to the negative control ...

Embodiment 2

[0054] Cinnamaldehyde reverses resistance to ceftriaxone sodium in drug-resistant Salmonella in vivo

[0055] 1. The protection rate of the intraperitoneal infection model of drug-resistant Salmonella in mice: the test mice were divided into blank control group, challenge group, cinnamaldehyde only group, ceftriaxone sodium only group and combined drug treatment group, 12 in each group. Except for the blank control group (inoculated with the same amount of PBS solution), the mice in each group were given 0.3 mL of 1×10^8 CFU of drug-resistant Salmonella for infection. 3 hours after infection, mice in the cinnamaldehyde-only group were treated with cinnamaldehyde alone (50 mg / kg) by oral administration, and ceftriaxone-only group mice were treated with ceftriaxone sodium alone (200 mg / kg) by intramuscular injection , and at the same time oral cinnamaldehyde combined with intramuscular injection of ceftriaxone sodium to treat the combined administration group mice. Continuous ...

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Abstract

The invention provides application of cinnamyl aldehyde combined with ceftriaxone sodium. The application is mainly used for preparing drugs for preventing and treating drug-resistant bacterial infection. The cinnamyl aldehyde can also be used as a synergist of the ceftriaxone sodium to prepare medicines for preventing and treating salmonella enteritidis infection. Research finds that combined use of the ceftriaxone sodium and the ceftriaxone sodium can have synergistic antibacterial activity on drug-resistant gram-negative drug-resistant bacteria, and can promote intracellular accumulation of the ceftriaxone sodium by damaging bacterial membranes and increasing membrane permeability, inhibit expression of drug-resistant genes, induce bacteria to enter a high metabolic state, improve the survival rate of the mouse drug-resistant salmonella enteritidis in abdominal cavity infection, improve intestinal inflammation, prevent intestinal colonization of bacteria, and reduce the dosage of the ceftriaxone sodium.

Description

technical field [0001] The invention belongs to the technical field of combined application of Chinese and Western medicines, and in particular relates to the application of cinnamaldehyde combined with ceftriaxone sodium. Background technique [0002] Salmonella is a common pathogen in animal-derived diseases and food-borne diseases. It can cause a variety of infectious diseases of poultry and livestock, and can also cause human infection. It has important public health significance. In recent years, due to the irrational use and abuse of antibiotics, the drug resistance of Salmonella has continued to spread, which has brought about potential safety hazards for human medication. With the increasingly strict supervision of veterinary antibiotics in my country, the research on traditional Chinese veterinary medicine has been paid more and more attention. At the same time, there are more and more studies on the combination of traditional Chinese medicine and antibiotics to inh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K31/11A61P31/04A61P1/00
CPCA61K31/546A61K31/11A61P31/04A61P1/00A61K2300/00Y02A50/30
Inventor 尹立子苟玉虹王涛李欣越舒刚谷可欣唐廷
Owner SICHUAN AGRI UNIV
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