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Method for judging cognitive impairment degree of Parkinson's disease by combining iconography with serum GDNF index

A technology for cognitive impairment and Parkinson's disease, which can be used in neural learning methods, image enhancement, image analysis, etc.

Pending Publication Date: 2021-12-28
XUZHOU MEDICAL UNIV
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Problems solved by technology

There is evidence that after the death of PD patients, there are changes in the expression and dysfunction of GDNF in the brain, and it is confirmed that the synchronous changes of GDNF in the circulation level, its impact on PD with cognitive dysfunction and its correlation with clinical status need to be further studied Research

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  • Method for judging cognitive impairment degree of Parkinson's disease by combining iconography with serum GDNF index
  • Method for judging cognitive impairment degree of Parkinson's disease by combining iconography with serum GDNF index
  • Method for judging cognitive impairment degree of Parkinson's disease by combining iconography with serum GDNF index

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Embodiment Construction

[0037] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them.

[0038] as attached Figure 1-7 As shown, the method for judging the degree of cognitive impairment in Parkinson's disease with imaging combined with serum GDNF indicators includes the following steps:

[0039]S1. GE3.0 TMRI scanning for the included subjects: each subject underwent non-contrast-enhanced MRITWI2 sequence and 3DT1WI brain volume sequence scanning as the baseline, using three-dimensional positioning, axial T1W1 scanning, 192 layers, full range Brain, and use the diffusion weighted-echo planar sequence, with the joint line as the scanning baseline, oblique axial DTI scanning, and finally collect BOLD images, a total of 36 layers. Among them...

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Abstract

The invention discloses a method for judging the cognitive impairment degree of Parkinson's disease by combining iconography with serum GDNF index, and relates to the technical field of judgment of the degree of cognitive impairment of Parkinson's disease, in particular to a method for judging the cognitive impairment degree of Parkinson's disease through combination of iconography and a serum GDNF index, comprising the following steps: S1, performing GE3.0 TMRI scanning on a subject; and S2, transmitting the original iconography image file from the MR scanner to a computer by using eFilmWorkstation, and storing the original iconography image file. According to the method, network connectivity indexes in imaging of three groups of patients are detected and analyzed, degree center values of right frontal lobes and apical lobes are found to be changed, whether the patients suffer from diseases or not can be well predicted in combination with the GDNF level, the cognitive impairment degree can be well predicted in combination with the PD disease course and the medicine taking condition-LED, and in addition, after the cerebral cortex thickness is measured, it is found that the correlation between the thickness of the left hemisphere frontal middle gyrus cortex and each cognitive domain score is maximum, and light and moderate cognitive impairments of PD can be effectively distinguished after the combination of serum GDNF indexes, PD disease courses and educational degrees.

Description

technical field [0001] The invention relates to the technical field of judging the degree of cognitive impairment of Parkinson's disease, in particular to a method for judging the degree of cognitive impairment of Parkinson's disease by combining imaging with serum GDNF index. Background technique [0002] Cognitive impairment in Parkinson's disease is very common and highly prevalent, and evidence suggests that cognitive impairment often precedes motor symptoms. At all stages of the PD progression, concomitant cognitive impairment leads to a marked increase in mortality and affects major activities of daily living. Then, for PD with cognitive impairment, or in the prodromal stage of clinical PD, can we find biomarkers that can reflect the process of neuron degeneration early and are easy to obtain, so as to improve the prediction of PD process and may be used as future mechanism targets for treatment, or as a risk factor for identifying PD. This will facilitate early dete...

Claims

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Application Information

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IPC IPC(8): G06T7/00G06K9/62G06T7/60G06N3/04G06N3/08
CPCG06T7/0012G06T7/60G06N3/08G06T2207/30096G06N3/045G06F18/23213
Inventor 唐传喜黄思婷王月刘业豪高殿帅
Owner XUZHOU MEDICAL UNIV
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