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Industrial-grade preparation method and product of traditional Chinese medicine composition for preventing and treating diabetic peripheral neuropathy

A technology for peripheral neuropathy and composition, applied in the field of industrial-grade preparation of traditional Chinese medicine compositions, can solve the problems of restricting the large-scale application of traditional Chinese medicine compositions, reducing the activity and yield of traditional Chinese medicine compositions, and shortening the production cycle and reducing the The effect of dosage and reduction of production cycle

Active Publication Date: 2022-07-12
王钢柱
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the preparation method of the traditional Chinese medicine composition for the treatment of diabetic peripheral neuropathy developed by the present inventor and other researchers is more suitable for small-dose preparation in the laboratory, or there will be problems after the laboratory preparation method is directly enlarged to the industrial level. The activity of traditional Chinese medicine composition products is reduced, the yield is reduced, or the cost is increased and the problem of waste is caused, which greatly restricts the clinical application of traditional Chinese medicine compositions for the treatment of diabetic peripheral neuropathy

Method used

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  • Industrial-grade preparation method and product of traditional Chinese medicine composition for preventing and treating diabetic peripheral neuropathy
  • Industrial-grade preparation method and product of traditional Chinese medicine composition for preventing and treating diabetic peripheral neuropathy
  • Industrial-grade preparation method and product of traditional Chinese medicine composition for preventing and treating diabetic peripheral neuropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Aconite 19.6Kg, Guizhi 6.6Kg, Astragalus 5.0Kg, Salvia 23.0Kg, Chuanxiong 6.8Kg, Angelica 19.5Kg, Red Peony 3.5Kg, Ephedra 7.0Kg, Asarum 13.3Kg, Tuckahoe 7.8Kg, Achyranthes 23.2kg, Anemarrhena 19.5Kg.

[0041] Take the above-mentioned medicinal materials and add water to decoct three times, add 1238.5Kg of water for the first decoction, decoct for 1 hour, add 928.8Kg of water for the second decoction and the third decoction respectively, decoct for 40 minutes, combine the decoctions, filter, and concentrate the filtrate to obtain a concentrated solution. paste. The concentrated paste is directly transferred to the alcohol precipitation tank, and under stirring, the interlayer tank is filled with circulating condensed water to accelerate the cooling, and reach room temperature in 2-4 hours; then add 95% ethanol to carry out alcohol precipitation operation, and take the supernatant. The ethanol is recovered from the liquid and concentrated to a relative density of 1.10-1...

Embodiment 2

[0043] Aconite 18Kg, Guizhi 12Kg, Astragalus 42Kg, Salvia miltiorrhiza 21Kg, Chuanxiong 13Kg, Angelica 16Kg, Chishao 3Kg, Ephedra 6Kg, Asarum 11.5Kg, Tuckahoe 6.5Kg, Achyranthes 20Kg, Anemarrhena 17Kg.

[0044] Take the above-mentioned medicinal materials and add water to decoct three times, add 1488Kg of water for the first decoction, decoct for 1 hour, add 1116Kg of water for the second decoction and the third decoction respectively, decoct for 40 minutes, combine the decoctions, filter, and concentrate the filtrate to obtain a concentrated paste. The concentrated paste is directly transferred to the alcohol precipitation tank, and under stirring, the interlayer tank is filled with circulating condensed water to accelerate the cooling, and reach room temperature in 2-4 hours; then add 95% ethanol to carry out alcohol precipitation operation, and take the supernatant. The ethanol is recovered from the liquid and concentrated to a relative density of 1.10-1.25g / cm 3 Clear the ...

Embodiment 3

[0048] Aconite 18Kg, Guizhi 12Kg, Astragalus 42Kg, Salvia miltiorrhiza 21Kg, Chuanxiong 13Kg, Angelica 16Kg, Chishao 3Kg, Ephedra 6Kg, Asarum 11.5Kg, Tuckahoe 6.5Kg, Achyranthes 20Kg, Anemarrhena 17Kg.

[0049] Take the above-mentioned medicinal materials and add water to decoct three times, add 1488Kg of water for the first decoction, decoct for 1 hour, add 1116Kg of water for the second decoction and the third decoction respectively, decoct for 40 minutes, combine the decoctions, filter, and concentrate the filtrate to obtain a concentrated paste. The concentrated paste is directly transferred to the alcohol precipitation tank, and the alcohol precipitation liquid is quickly separated by an explosion-proof centrifugal filter after stirring, and the alcohol precipitation separation can be completed in 2-4 hours; Density is 1.10-1.25g / cm 3 Clear the paste, filter; add lactose or dextrin 2-5 times the weight of the clear paste to the clear paste for spray drying and granulation...

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Abstract

The invention provides an industrial-grade preparation method of a traditional Chinese medicine composition for preventing and treating diabetic peripheral neuropathy, its product and use. The decoction is cyclically applied, the decoction is filtered, and the filtrate is concentrated to obtain a concentrated paste; the concentrated paste is transferred into an alcohol precipitation tank, and under stirring, the interlayer tank is filled with circulating condensed water to accelerate the cooling, 2-4 reach room temperature within an hour; then add 95% ethanol under high-speed stirring to carry out alcohol precipitation operation, take the supernatant to recover ethanol, and concentrate to a relative density of 1.10-1.25g / cm 3 Clean the paste; add 10% 95% ethanol to the extract paste for mixing, add or not add an appropriate amount of auxiliary materials to control the inlet air temperature of 25-40°C and relative humidity of 50-70% for spray drying or spray drying granulation. The preparation method of the present invention is especially suitable for industrial production, and the overall efficiency of the preparation method is high, and the yield of effective components is significantly improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an industrial-grade preparation method of a traditional Chinese medicine composition for preventing and treating diabetic peripheral neuropathy, its product and use. Background technique [0002] In recent years, the incidence of diabetes has increased year by year. Diabetes Peripheral Neuropathy (DPN) is one of the most common chronic complications of diabetic patients, which brings a heavy burden to patients and gradually becomes a medical hotspot. The clinical manifestations of diabetic peripheral neuropathy are diverse. In addition to the symptoms of polydipsia, polyuria, and elevated blood sugar, patients may develop muscle atrophy and diabetic foot with special manifestations such as limb numbness, hypoesthesia, and persistent pain. Diabetic peripheral neuropathy is one of the main causes of non-traumatic amputation due to its insidious and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8964A61K36/90A61P3/10A61P25/02A61P9/14
CPCA61K36/481A61K36/268A61K36/537A61K36/54A61K36/90A61K36/896A61K36/232A61K36/236A61K36/17A61K36/714A61K36/71A61K36/65A61K36/21A61K36/8964A61P3/10A61P25/02A61P9/14A61K2236/331A61K2236/55A61K2236/39A61K2300/00
Inventor 王钢柱
Owner 王钢柱
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