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Compound fungicide containing N-(2-(2,4-dichlorophenoxyl)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-amide and procymidone

A technology of chlorophenyl ether amide and fungicides, applied in the direction of fungicides, biocides, biocides, etc., can solve the problems of difficult research and development of fungicides, difficult to launch, etc., to achieve drug resistance, simple use, and good effect Effect

Active Publication Date: 2021-12-14
ZHEJIANG FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problem with this method is that in fact, it is very difficult to develop fungicides with a new mechanism of action, and it is difficult to launch a new type of fungicide with a different mechanism of action from the existing ones in an average of 10 years.
That is to say, the method is feasible in theory, but it is very limited in practice.

Method used

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  • Compound fungicide containing N-(2-(2,4-dichlorophenoxyl)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-amide and procymidone
  • Compound fungicide containing N-(2-(2,4-dichlorophenoxyl)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-amide and procymidone
  • Compound fungicide containing N-(2-(2,4-dichlorophenoxyl)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-amide and procymidone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, the bacteriostatic activity of chlorphenamide to boscalid resistance and sensitive strains:

[0030] The sensitivity of boscalid-resistant (R) and sensitive (S) Botrytis cinerea strains (Table 1) to chlorphenamide and other SDHIs was determined by mycelial growth method. Results: The 10 boscalid-resistant (R) strains all showed resistance (R) to flufenapyridine, which is also SDHI, that is, there was complete cross-resistance. 8 of the 10 boscalid-resistant (R) strains, the ratio was 80%, also showed resistance (R) to fluopyram, which is also SDHI. It shows that DHI such as fluopyram and flufenapyr can not effectively control Botrytis cinerea which has developed resistance to boscalid.

[0031] Unexpectedly, the 10 boscalid-resistant (R) strains were all sensitive (S) to chlorphenamide, which is also SDHI. Sensitivity of 10 boscalid-sensitive (S) strains to chlorphenamide, which is also SDHI (EC 50 ) between 1.03-2.28mg / L, with an average of 1.465mg / L; ...

Embodiment 2

[0034] Example 2. Molecular docking of chlorphenamide and boscalid with SDH proteins of boscalid resistant and sensitive strains

[0035] Chlorphenamide and boscalid belong to the same class of drugs SDHI. Generally speaking, there is cross-resistance between the same type of pesticides, that is, the Boscalid boscalid produced by Botrytis cinerea has developed resistance, so chlorophenyl ether amide can no longer be used for the effective control of resistant botrytis. . However, the present invention unexpectedly finds that the fact does not conform to the general situation, and there is no cross-resistance between chlorphenamide and other SDHIs such as boscalid and flufenapyridine. Existing studies have shown that the resistance of Botrytis cinerea to boscalid is caused by the mutation of the B subunit of succinate dehydrogenase, but there are many related mutation types, among which H272 R / L and P225L / F / T more common. The present invention further analyzes the molecular ...

Embodiment 3

[0037] Embodiment 3, Botrytis cinerea population is sensitive to chlorophenyl ether amide

[0038] Collect Botrytis cinerea from grapes, strawberries, tomatoes and other crops, and measure the sensitivity of 239 strains of Botrytis cinerea to chlorophenyl ether amide, and find that 7 (2.9%) bacterial strains cannot be inhibited by chlorophenyl ether amide (Table 2), EC 50 The value is between 12.45-33.85mg / L.

[0039] The present invention selects 4 strains from the above-mentioned 7 gray mold bacterial strains that cannot be inhibited by chlorophenyl ether amide, and selects 4 strains from 232 strains that can be inhibited by chlorophenyl ether amide, and further measures the effect of these bacterial strains on other gray mold Sensitivity of commonly used agents for mildew, the results showed that the strains were more sensitive to procymidone, while thiophanate-methyl, pyrimethanil and diethofocarb had almost no inhibitory activity on these strains, fenhexamid and azoxystr...

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Abstract

The invention discloses a compound fungicide. The compound fungicide comprises the following components in percentage by weight: 10%-90% of procymidone and 90%-10% of N-(2-(2,4-dichlorophenoxyl)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-amide. The invention also discloses a fungicide preparation prepared from the compound fungicide. The compound fungicide disclosed by the invention is used for preventing and treating diseases caused by gray mold, sclerotiniose, southern blight and alternaria fungi, and particularly is used for preventing and treating diseases caused by drug-resistant gray mold, sclerotiniose, southern blight and alternaria fungi. The drug resistance is the drug resistance to boscalid.

Description

technical field [0001] The invention relates to a combined fungicide, in particular to a compound fungicide used for preventing and treating diseases caused by drug-resistant gray mold, sclerotinia, candida and Alternaria fungi. Background technique [0002] Phytopathogen resistance refers to wild-type plant pathogen individuals or populations that are originally sensitive to fungicides, and their sensitivity to fungicides decreases due to genetic variation, which is one of the most important issues in the field of plant chemical protection. Cross Resistance (Cross Resistance) refers to the phenomenon that pests also develop resistance to a drug or a class of drugs other than the drug used due to the same resistance mechanism, or similar mechanism of action, or similar chemical structure, which is called cross resistance. . Long-term use of a single fungicide will not only produce resistance, but also serious cross-resistance problems. Generally speaking, there is cross-re...

Claims

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Application Information

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IPC IPC(8): A01N43/56A01N37/32A01P3/00
CPCA01N43/56A01N37/32
Inventor 张传清吴鉴艳毛程鑫
Owner ZHEJIANG FORESTRY UNIVERSITY
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