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Joint detection serum marker for early diagnosis of lung adenocarcinoma and application of joint detection serum marker

A serum marker, combined detection technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of lack of research, low sensitivity and specificity, etc.

Pending Publication Date: 2021-11-23
ZHENGZHOU UNIV
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  • Application Information

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Problems solved by technology

Clinically, carcinoembryonic antigen (CEA) as a traditional serum tumor marker is widely used in the auxiliary diagnosis of lung cancer, but the single detection still has the disadvantages of low sensitivity and specificity.
As the first type of antibody produced in the humoral immune response, IgM autoantibodies have great potential as an early diagnostic indicator for lung cancer, but there is no relevant research yet

Method used

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  • Joint detection serum marker for early diagnosis of lung adenocarcinoma and application of joint detection serum marker
  • Joint detection serum marker for early diagnosis of lung adenocarcinoma and application of joint detection serum marker
  • Joint detection serum marker for early diagnosis of lung adenocarcinoma and application of joint detection serum marker

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experiment example

[0034] 1. Collection and preparation of serum samples

[0035] 1.1 Collection of serum samples

[0036] A total of 430 subjects were included in this study, which were divided into discovery group and verification group. The discovery group was used to screen the IgM autoantibody indicators with high diagnostic value for lung adenocarcinoma. The verification group was used to verify the candidate IgM autoantibody indicators, and combined with CEA to build a diagnostic model.

[0037] The serum samples of all subjects were collected in a tertiary hospital in Henan Province from 2016 to 2019. The basic information, pathological stage and serum CEA level of all subjects were obtained with the consent of the patients and the approval of the Institutional Review Board and the Hospital Ethics Committee In some cases, it is summarized and sorted through the internal system of the hospital. Among them, the test results of serum CEA were provided by the laboratory department of the h...

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Abstract

The invention discloses a joint detection serum marker for early diagnosis of lung adenocarcinoma, comprising IgM autoantibodies of TSHR, ERBB2, Survivin, PIK3CA and JAK2. An ELISA serum detection kit is prepared by using a specific protein corresponding to the joint detection serum marker. The joint detection serum marker plays an important role in improving the sensitivity, specificity and accuracy of early diagnosis of lung adenocarcinoma. Meanwhile, the joint detection serum marker is combined with a CEA serum marker to construct a diagnosis model, and a serological detection method which is high in sensitivity, strong in specificity, low in cost and capable of assisting clinical diagnosis of lung adenocarcinoma is provided.

Description

technical field [0001] The invention belongs to the technical field of biomedical detection, and in particular relates to a combined detection serum marker that can be used for early diagnosis of lung adenocarcinoma and its application. Background technique [0002] In 2020, according to statistics, there will be 2.2 million new cases of lung cancer and 1.8 million deaths, accounting for 11.4% and 18.0% of all cancers respectively. It is the second most common cancer in the world with the highest mortality rate. Lung adenocarcinoma, as the most common histological subtype of non-small cell lung cancer, accounts for about 40% of lung malignancies, and mostly occurs in women and non-smokers. A large number of studies have shown that the 5-year disease-free survival rate of patients with adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) can be close to 100% if they undergo radical surgery. It can be seen that early diagnosis and timely and effective trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/543
CPCG01N33/57423G01N33/57488G01N33/54313
Inventor 代丽萍张建营张雪王雨林王晓欧阳松云赵春玲
Owner ZHENGZHOU UNIV
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