Brightening booster technology and brightening ampule

A technology of brightness and composition, which can be used in cosmetic preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve problems such as side effects

Pending Publication Date: 2021-11-12
MARY KAY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many attempts were ineffective, only resolved one or a few undesired results, or caused unacceptable side effects themselves

Method used

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  • Brightening booster technology and brightening ampule
  • Brightening booster technology and brightening ampule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] (exemplary formulation)

[0104] Formulations having the ingredients disclosed herein are prepared as topical skin compositions. In some instances, topical skin compositions can be formulated as ampoules, liquids, serums, creams, gels, gels, lotions, or gel-emulsions. The formulations in Table 1 are examples of topical skin compositions prepared as ampoules.

[0105] Table 1^

[0106] Element Concentration % (by weight) water 69 PEG-8 15 Propylene Glycol 5 glycerin 4.3 Nicotinamide 3 Ethoxydiglycol 2 Phenoxyethanol 0.5 xanthan gum 0.35 plant amino acid 0.3 ferulic acid 0.25 Sodium citrate 0.2 excipient* Appropriate amount

[0107] ^ The formulation can be prepared by mixing the ingredients in a beaker with heating at 70°C to 75°C until homogeneous. The formulation can then be cooled to standard room temperature (20°C to 25°C). Also, if desired, additional ingredients can be added...

Embodiment 2

[0110] (material used)

[0111] The active ingredients in Table 2 were used to obtain the following in vitro data.

[0112] Table 2

[0113] Element supplier Nicotinamide DSM plant amino acid Carrubba ferulic acid Kinetic

Embodiment 3

[0115] (B16 Pigmentation Analysis)

[0116] Melanogenesis is the process by which melanocytes produce melanin, the naturally occurring pigment that gives skin, hair and eyes their color. Inhibiting melanogenesis is beneficial in preventing skin darkening and lightening age-related dark spots.

[0117] The B16 Pigmentation Assay utilizes the immortalized mouse melanoma cell line B16-F1 melanocytes (ATCC) to analyze the effect of the active ingredients niacinamide, plant amino acids and ferulic acid alone or in combination on melanin production. The endpoints of these assays are spectrophotometric measurements of melanin production and cellular viability.

[0118] B16-F1 melanocytes were cultured in T150 tissue culture flasks at 37 °C in 10% CO in standard DMEM growth medium supplemented with 10% fetal bovine serum (Mediatech) and 1% penicillin / streptomycin. 2 cultured until subconfluent. Cells in one confluent T150 tissue culture flask were trypsinized and resuspended in DME...

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Abstract

The present invention relates generally to methods of use and compositions useful to reduce the appearance of uneven skin tone, reduce the appearance of skin discoloration, reduce visible skin discoloration, improve the appearance of uneven skin tone, improve the brightness of skin, prevent the production of discoloration, limit uneven skin tone from appearing on skin, increase moisture levels, attract water, brighten, renew the skin, increase skin radiance, soothe the skin, increase skin smoothness, hydrate skin, smooth skin, brighten skin, reduce signs of aging in skin, and / or increase the efficacy of cosmetic products to brighten, renew the skin, increase skin radiance, sooth the skin, increase skin smoothness, hydrate skin, smooth skin, brighten skin, and / or reduce signs of aging in skin. The composition includes a combination of niacinamide, vegetable amino acids, and ferulic acid.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to U.S. Provisional Patent Application No. 63 / 023184, filed May 11, 2020, which is incorporated herein by reference in its entirety. technical field [0003] The present invention generally relates to cosmetic compositions and methods useful for reducing or preventing skin discoloration, reducing or improving uneven skin tone, improving skin luminosity, and / or increasing cosmetics for reducing or preventing skin discoloration, reducing or improving uneven skin tone, and improving skin The effect of brightness. In particular, the composition may comprise niacinamide, phytoamino acids and ferulic acid. Background technique [0004] Various factors can stress the skin in different ways including, for example, aging, chronic exposure to adverse environmental factors, malnutrition, fatigue, stress, seasonal changes, and other extrinsic and intrinsic factors that can damage th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/36A61K8/44A61K8/86A61K8/73A61K8/34A61Q19/02A61Q19/00
CPCA61K8/675A61K8/36A61K8/44A61K8/86A61K8/345A61K8/73A61Q19/02A61Q19/00A61K2800/782A61K8/673A61K8/9789A61K8/34A61K8/362A61K8/365A61K8/39A61K2800/5922A61Q19/007
Inventor 蒂凡尼·卡尔吉赛·卡拉哈斯蒂大卫·甘万里·赵
Owner MARY KAY INC
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