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Fibronectin liquid wound spray dressing as well as preparation method and application thereof

A fibronectin and liquid technology, applied in dressings, non-adhesive dressings, bandages, etc., can solve the problems that cannot meet the needs of patients for high-quality wound healing, and achieve accelerated wound healing process, significant film-forming performance, and good physical properties. Barrier effect

Pending Publication Date: 2021-11-02
上海纤瑞生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional wound dressings in the past, such as bandages, gauze, cotton balls, etc., can no longer meet the needs of patients for high-quality wound healing. Therefore, various new wound dressings have emerged, such as biological animal skin, animal collagen, Plant rhizomes, etc.; synthetic polyurethane, alginate composite dressings, chitin, etc.; biochemical double-layer molecular films, polymers and biological materials, etc.

Method used

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  • Fibronectin liquid wound spray dressing as well as preparation method and application thereof
  • Fibronectin liquid wound spray dressing as well as preparation method and application thereof
  • Fibronectin liquid wound spray dressing as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Take high-concentration fibronectin, dilute and dissolve it with purified water, and then filter and sterilize it through microporous membrane filtration to obtain a fibronectin feed solution. Take 0.05 g of fibronectin feed solution for use;

[0022] (2) Put the glycerin in a glass beaker, put it in a high-pressure steam sterilizer, sterilize the glycerin by high-pressure steam sterilization, and cool it to room temperature to obtain sterilized glycerin. Take 200ml of sterilized glycerin for later use;

[0023] (3) Dissolve polyethylene glycol in purified water, put it in a glass beaker, put it in a high-pressure steam sterilizer, sterilize it by high-pressure steam sterilization, and cool it to room temperature to obtain sterilized polyethylene glycol. Get 1g of sterilized polyethylene glycol for subsequent use;

[0024] (4) Mix 0.05g of fibronectin feed solution, 200ml of sterilized glycerin, and 1g of sterilized polyethylene glycol, stir, then add 5g of dipotass...

Embodiment 2

[0026] (1) Take high-concentration fibronectin, dilute and dissolve it with purified water, and then filter and sterilize it through microporous membrane filtration to obtain a fibronectin feed solution. Take 0.1 g of the fibronectin feed solution for use;

[0027] (2) Put the glycerin in a glass beaker, put it in a high-pressure steam sterilizer, sterilize the glycerin by high-pressure steam sterilization, and cool it to room temperature to obtain sterilized glycerin. Take 400ml of sterilized glycerin for use;

[0028] (3) Dissolve polyethylene glycol in purified water, put it in a glass beaker, put it in a high-pressure steam sterilizer, sterilize it by high-pressure steam sterilization, and cool it to room temperature to obtain sterilized polyethylene glycol. Get 2g sterilized polyethylene glycol for subsequent use;

[0029] (4) Mix 0.1g of fibronectin feed solution, 400ml of sterilized glycerin, and 2g of sterilized polyethylene glycol, stir, then add 10g of dipotassium hy...

Embodiment 3

[0031] (1) Take high-concentration fibronectin, dilute and dissolve it with purified water, and then filter and sterilize it through microporous membrane filtration to obtain a fibronectin feed solution. Take 0.1 g of the fibronectin feed solution for use;

[0032] (2) Put the glycerin in a glass beaker, put it in a high-pressure steam sterilizer, sterilize the glycerin by high-pressure steam sterilization, and cool it to room temperature to obtain sterilized glycerin. Take 200ml of sterilized glycerin for later use;

[0033] (3) Dissolve polyethylene glycol in purified water, put it in a glass beaker, put it in a high-pressure steam sterilizer, sterilize it by high-pressure steam sterilization, and cool it to room temperature to obtain sterilized polyethylene glycol. Get 5g sterilized polyethylene glycol for subsequent use;

[0034] (4) Mix 0.1g of fibronectin feed solution, 200ml of sterilized glycerin, and 5g of sterilized polyethylene glycol, stir, then add 5g of dipotassi...

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Abstract

The invention belongs to the field of medical dressings, and particularly relates to a fibronectin liquid wound spray dressing as well as a preparation method and application thereof. The fibronectin liquid wound spray dressing consists of fibronectin, polyethylene glycol, glycerol, dipotassium phosphate, purified water and the like. In the invention, fibronectin has an adhesion effect, polyethylene glycol and glycerol have film-forming properties, and fibronectin, polyethylene glycol and glycerol are combined to form a very good protective film on the surface of a wound, so that a very good physical barrier effect on the wound is achieved, external dust, bacteria and other foreign matters are prevented from entering the wound, and wound healing is further facilitated, and a nursing effect is achieved on wounds and surrounding skin tissues. The dipotassium phosphate plays a role in stabilizing the formula and plays a role in promoting mutual fusion of other components. The fibronectin liquid wound dressing is definite in curative effect, safe and reliable to use, simple in preparation method and free of side effects, and has good practical value and medical value.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a fibronectin liquid wound spray dressing and a preparation method and application thereof. Background technique [0002] Wound dressing refers to covering the wound surface in the process of wound treatment and healing, protecting the wound surface, avoiding or controlling wound infection caused by external foreign bodies or bacteria, and providing a good environment for wound healing. With the aging of the global population and the increase of chronic wounds and various wounds, the demand for wound dressings is increasing day by day. However, the traditional wound dressings in the past, such as bandages, gauze, cotton balls, etc., can no longer meet the needs of patients for high-quality wound healing. Therefore, various new wound dressings have emerged, such as biological animal skin, animal collagen, Plant rhizomes, etc.; synthetic polyurethane, alginate composite dressings,...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61F13/00
CPCA61L26/0042A61L26/0019A61L26/0076A61L26/0066A61L2300/252A61L2300/418A61L2300/412A61F13/01012C08L89/00C08L71/02
Inventor 王斌张世阳郭凤玲沈宏王浩晴
Owner 上海纤瑞生物技术有限公司
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