Synthesis method and application of 2-undecyloxy-1-ethanol
A synthetic method and alkoxyl technology, applied in the fields of application, botany equipment and method, ester reaction to prepare ether, etc., can solve the problems of incapable of large-scale production, long reaction steps, low reaction yield, etc., and achieve low product cost , mild and controllable reaction conditions, high reaction yield
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Embodiment 1
[0032] A kind of synthetic method of 2-undecyloxy-1-ethanol, specifically comprises the following steps:
[0033] Add 136.4g of ethylene glycol to a 250ml three-necked flask, add 12.6g of potassium hydroxide, then add a homogeneous catalyst 18 crown-6 and raise the temperature to 85 degrees Celsius for 3 hours; then add 42.8g of 1-bromoundecane dropwise and heat up Reaction at 110° C. for 8 hours; extraction after liquid separation, combined organic phases, concentration, and high vacuum distillation to obtain 32.4 g of a product with a purity of 99%.
Embodiment 2
[0034] Embodiment 2: Pilot-scale scale-up preparation
[0035] A kind of synthetic method of 2-undecyloxy-1-ethanol, specifically comprises the following steps:
[0036] (1) Add 1#16.38kg ethylene glycol, 1.5kg potassium hydroxide 2#, 290g homogeneous catalyst 18guan-63# to the 30L reactor in sequence, heat up and stir to 85°C for 32h;
[0037] (2) Add 4# dropwise to the reactor, heat up to 110°C after the dropwise addition, reflux and stir the reaction, take samples every 2h and react for 5h; detect the progress of the reaction;
[0038] (3) Stop the reaction when the reaction raw material is below 10%, and the reaction by-product diether is below 9%;
[0039] (4) Add 5L of water to the reaction solution, stir to inactivate, and separate the liquids; the aqueous phase is extracted with 5L*3PE, and all organic phases are combined, dried by adding 3.0kg of anhydrous sodium sulfate, concentrated to dryness under reduced pressure, and finally obtained 5.1kg of crude product, th...
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