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Ganoderma lucidum extract as well as preparation method and application thereof

The technology of extract and water extract is applied in the field of pseudo lucidum extract and its preparation, which can solve the problems such as no pharmacological research report on anti-gastric ulcer, and achieve the effects of anti-gastric ulcer, effect and inhibition of inflammatory response.

Active Publication Date: 2021-10-19
惠州卫生职业技术学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies have shown that False Mushroom has good anti-inflammatory and anti-oxidative effect

Method used

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  • Ganoderma lucidum extract as well as preparation method and application thereof
  • Ganoderma lucidum extract as well as preparation method and application thereof
  • Ganoderma lucidum extract as well as preparation method and application thereof

Examples

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preparation example Construction

[0025] The invention provides a preparation method (abbreviation method) of the extract of False Chiba, which is characterized in that the method comprises the preparation of the water extract of False Fructus and the preparation of the ethanol extract of False Fructus;

[0026] The preparation of the water extract of False Chiba includes: taking the powder of False Fructus fruiting body, accurately weighing, adding water, heating and refluxing at 90°C to 100°C for at least one extraction (preferably three times), each extraction for at least 30min ( Preferably 1h), filter after each extraction to obtain the filtrate; after all the extractions are completed, combine all the filtrates obtained; then concentrate the combined filtrate under reduced pressure to make 1 mL of liquid extract equivalent to 1 g of crude drug, and flow immersion The ointment is the water extract of False Chiba;

[0027] The preparation of the ethanol extract of False Chrysanthemum is specifically: take ...

Embodiment 1

[0042] Take 800g of False Fructus fruiting body powder, weigh it accurately, heat and reflux at 98-100°C for 3 times, 1 hour each time, add 16L of water for the first time, add 12.8L of water for the second time, add 12.8L of water for the third time, after each extraction Filtrate to obtain the filtrate; after all the extractions are completed, combine all the obtained filtrates; then concentrate the combined filtrate to 800ml under reduced pressure to make 1mL liquid extract equivalent to 1g standard of crude drug, the liquid extract is False Zhishui Extract.

[0043] After testing, the physical and chemical indicators of the nucleosides in Example 1 are shown in Table 1; the polysaccharide content is 7.20 mg / ml, and the RSD value is 2.92%.

[0044] Table 1

[0045] Nucleoside species Cytidine Uridine Guanosine Adenosine total Sample content (mg / ml) 0.2465 0.6301 0.4064 0.4989 1.7819 RSD(%) 3.87 3.00 4.40 3.99 1.53

Embodiment 2

[0047] Take 800g of False Chiba fruiting body powder, weigh it accurately, heat and reflux at 75°C for 3 times, 1 hour each time, add 16L of 75% ethanol for the first time, add 12.8L of 75% ethanol for the second time, add 75% ethanol for the third time 12.8L, after each extraction, filter to obtain the filtrate; after all the extractions are completed, combine all the filtrates obtained; then concentrate the combined filtrate to 800ml under reduced pressure to make 1mL liquid extract equivalent to 1g standard crude drug, flow The extract is the ethanol extract of False Chrysanthemum.

[0048] After testing, the content of triterpenes and sterols in Example 2 is 3.60 mg / ml, with an RSD value of 2.51%; the content of ergosterol is 0.387 mg / ml, with an RSD value of 2.99%.

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Abstract

The invention discloses a ganoderma lucidum extract as well as a preparation method and application thereof. The preparation method comprises the steps of preparation of a ganoderma lucidum water extract and preparation of a ganoderma lucidum ethanol extract. The ganoderma lucidum extract comprises a ganoderma lucidum water extract and a ganoderma lucidum ethanol extract. The application refers to the application of the ganoderma lucidum extract in preparation of anti-gastric ulcer medicines and food. Pharmacological tests prove the effectiveness of the extract in anti-gastric ulcer, and reveal the anti-gastric ulcer action mechanism of the extract as follows: the extract inhibits NF-kB/NLRP3 of an inflammatory pathway by inhibiting NF-kB P65 nuclear migration, so proinflammatory factors of gastric mucosa tissues are down-regulated, the inflammatory response is inhibited, and the anti-gastric ulcer effect is realized.

Description

technical field [0001] The invention relates to the field of medicinal and edible fungi, in particular to an extract of pseudogum lucidum and its preparation method and application. Background technique [0002] False mushroom (Amauroderma rugosum) is a medicinal edible fungus with rich nutritional value and significant medicinal activity. It is considered as the "black mushroom" among the ancient six mushrooms and has a long history of application in China. False Mushroom belongs to the Ganodermaceae Pseudomonas in fungal taxonomy. It is commonly known as "Blood Mushroom" because of the white cap edge and the back of the cap of the young fruiting body, which will produce blood-like secretions when lightly touched. Ancient books and modern documents "Dai Yucheng, Tuli Gul, Cui Baokai, etc. Chinese Medicinal Fungi Illustrated [M]. Harbin, Heilongjiang: Northeast Forestry University Press, 2013:38-41. Antitumor, anti-inflammatory and diuretic effects. [0003] Gastric ulcer ...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P1/04A23L31/00A23L33/10
CPCA61K36/07A61P1/04A23L31/00A23L33/10A61K2236/331A61K2236/39A61K2236/51A61K2236/333A23V2002/00A23V2200/32A23V2250/208Y02A50/30
Inventor 麦艳珍
Owner 惠州卫生职业技术学院
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