Adult t-cell leukemia-lymphoma detection method

Abstract

An adult T-cell leukemia-lymphoma (ATL) detection method is provided which involves determining the presence or absence in a target biological sample of DNA methylation of at least one gene selected from the group consisting of SERPINB6, NELL2, THEMIS, ZSCAN18, LAIR1, CD7, RNF130, ZIK1, LYPD3, TMEM45B, POMC, FHIT, MDS2, HOOK1, SORCS3, C2orf40, ZNF662, SPG20, ZNF717, LZTFL1, KLHL34 and BCL9, wherein DNA methylation of at least one of the aforementioned genes indicates that the subject has developed or is at risk of developing ATL. By this means, a new detection method of adult T cell leukemia-lymphoma (ATL) is provided.

Description

technical field [0001] The invention relates to a detection method for adult T cell leukemia / lymphoma (ATL) and the like. Background technique [0002] Adult T-cell leukemia / lymphoma (ATL) is a peripheral T-cell tumor caused by retrovirus Human T-cell Lymphotropic Virus type-1 (Human T-cell Lymphotropic Virus type-1, HTLV-1) infection of T cells. The main route of HTLV-1 infection is breastfeeding, sexual intercourse, blood transfusion, etc. HTLV-1 infected people are distributed in Japan, the Caribbean coastal areas, Central Africa, South America and other places, and the number of infected people is estimated to be 5 million to 20 million (non-patented Literature 1). Japan's HT LV-1 infection is estimated to have 1.1 million people (non-patent document 1), of which 40 to 50% live in Kyushu and Okinawa, but in recent years, HTLV living in large cities such as Osaka, Tokyo, and Aichi -1 Infected people tend to increase. [0003] T cells infected with HTLV-1 undergo a mult...

AI Technical Summary

Problems solved by technology

However, about half of patients with low-grade ATL undergo acute transformation during the course of the disease, and their long-term prognosis is poor (Non-Patent Document 2)

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