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A kind of artemether derivative and its preparation method and application

A derivative, artemether technology, applied in the field of artemether derivatives with high anti-cancer biological activity and its preparation, can solve the problems of artemether-isatin splicing reports and other issues, and achieve great clinical application prospects, good Anti-tumor activity, the effect of great development value

Active Publication Date: 2022-06-03
PEKING UNIV SHENZHEN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the literature reports on artemether and isatin are concentrated on the study of their monomer derivatives, and there is no report on artemether-isatin splicing

Method used

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  • A kind of artemether derivative and its preparation method and application
  • A kind of artemether derivative and its preparation method and application
  • A kind of artemether derivative and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]

Embodiment 2

[0040] The difference with Example 1 is that the process parameters are different.

Embodiment 3

[0044] The difference with Example 1 is that the process parameters are different.

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Abstract

The present invention provides an artemether derivative with high anti-cancer biological activity. The artemether derivative has a chemical structure as shown in the following formula (I): the anti-tumor effect of CT3-1 prepared by the present invention is significantly better than that of the positive In contrast, it has good antitumor activity and strong druggability, and has great development value and clinical application prospect. The present invention also relates to the application and preparation method of the artemether derivative.

Description

A kind of artemether derivative and its preparation method and application technical field The present invention relates to the technical field of medicine, more particularly, to a kind of artemether derivative of high anticancer biological activity and preparation method and application thereof. Background technique [0002] Artemether is one of the derivatives of artemisinin and is an important antimalarial drug. In recent years, studies have reported that artemether It also has inhibitory effect on a variety of tumor cells, but its anti-tumor activity needs to be improved (BiolPharm Bull. 2019, 42 (10):1720‑1725. Breast Cancer. 2020, 27(2):243‑251.). Isatin is an important nitrogen heterocyclic compound It is widely used in the field of biomedicine. Studies have reported that isatin and its derivatives have antitumor effects (Bioorg Chem. 2020, 102: 104046. Guangdong Chemical Industry. 2015, 42(14): 106, 113.). Chemical splicing is considered to be an importa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/20A61P35/00A61K31/404
CPCC07D493/20A61P35/00Y02A50/30
Inventor 陈健陶成王庆文刘景锋何娟林献虎义平罗颖豪
Owner PEKING UNIV SHENZHEN HOSPITAL
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