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Genome structure variation detection method based on filtering and noise reduction

A detection method and genome technology, applied in the field of bioinformatics, can solve the problems of complex probe preparation, cumbersome operation steps, long time consumption, etc.

Inactive Publication Date: 2021-09-24
哈尔滨因极科技有限公司
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Problems solved by technology

However, the preparation of probes by this method is relatively complicated, and the operation steps are cumbersome and time-consuming.

Method used

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  • Genome structure variation detection method based on filtering and noise reduction
  • Genome structure variation detection method based on filtering and noise reduction
  • Genome structure variation detection method based on filtering and noise reduction

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Embodiment Construction

[0047] The following embodiments will further illustrate the present invention in conjunction with the accompanying drawings, and what provide are some specific embodiments of the present invention, and these embodiments just illustrate and do not represent all possibilities of the present invention, and the present invention is not limited to these embodiments The materials, reaction conditions or parameters mentioned in the above, anyone with experience in related fields can use other similar materials or reaction conditions to realize the gene copy number variation detection described in the present invention according to the principle of the present invention. These do not depart from the basic concepts described in the present invention.

[0048] As used herein, the words "comprises", "comprising", "having" or any other variation thereof are intended to cover a non-exclusive inclusion. For example, a process, method, article, or apparatus comprising listed elements is not...

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Abstract

The invention provides a genome structure variation detection method based on filtering and noise reduction. According to the genome copy number variation detection method based on filtering noise reduction, the characteristics of a chromosome sequence and the influence of the GC content of a base in the sequence on reading depth are considered; and on the basis of better preprocessing data, carrying out convolution operation on the read depth data and the Gaussian kernel function to obtain a scale space image function, carrying out edge detection and reference detection on the scale space image, determining candidate copy number areas, detecting copy number variation types and positions, and improving the copy number variation detection precision.

Description

technical field [0001] The invention relates to the field of bioinformatics, in particular to a genome copy number variation detection method based on filter noise reduction. Background technique [0002] The development of next-generation sequencing (New generation sequencing, NGS) technology is becoming more and more mature, various sequencing platforms emerge in an endless stream, the cost of gene sequence sequencing has dropped significantly, and the speed of sequencing is getting higher and higher, which makes the DNA sequence data generated by sequencing very Huge, the accuracy of data processing has become a top priority. [0003] Wavelet transform is a powerful tool to remove data noise in signal processing, and scale-space filtering is an important means to describe signals visually. For sequencing data in the field of bioinformatics, due to the high repeatability of the biological sequence itself and the inevitable errors in the sequencing process, it is often nec...

Claims

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Application Information

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IPC IPC(8): G16B20/10G16B30/00
CPCG16B20/10G16B30/00
Inventor 刘志岩刘珍王海宁姜玥
Owner 哈尔滨因极科技有限公司
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