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Coated and/or impregnated ureteral catheter or stent and manufacturing method thereof

A technology for coating and urinary catheters, which is applied in the direction of catheters, coatings, and pharmaceutical formulations, and can solve the problems of failing to improve the renal function of patients with cardiorenal syndrome

Inactive Publication Date: 2021-09-10
ROIVIOS LIMITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this clinical strategy does not improve renal function in patients with cardiorenal syndrome

Method used

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  • Coated and/or impregnated ureteral catheter or stent and manufacturing method thereof
  • Coated and/or impregnated ureteral catheter or stent and manufacturing method thereof
  • Coated and/or impregnated ureteral catheter or stent and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0334] Example 1 shows positioning tubes with openings of different sizes (which correspond to Figure 11 The liquid flow distribution of the embodiment of positioner 1330 shown in . As shown in Table 3, the closest opening (Q 6 ) is 0.48mm in diameter, and the farthest opening on the side wall of the tube (Q 5 ) has a diameter of 0.88mm, while the open distal end of the tube (Q 6 ) has a diameter of 0.97mm. Each opening is circular.

[0335] The flow distribution percentage and calculated volumetric flow are determined as follows.

[0336] Path to station B via the far end of the pipe (path 1)

[0337]

[0338] Route to Station B via side wall opening (Route 2)

[0339]

[0340] Route from station B to station C (path 1+path 2)

[0341]

[0342] Path to station C via side wall opening (path 3)

[0343]

[0344] Path from station C to station D (path 1+path 2+path 3)

[0345]

[0346] Route to station D via side wall opening (route 4)

[0347]

[03...

Embodiment 2

[0361] In Example 2, each opening has the same diameter and area. as table 4 and Figure 15A As shown, in this case, the flow distribution through the nearest opening accounts for 86.2% of the total flow through the pipe. The flow distribution via the second opening was 11.9%. Thus, in this example, it is calculated that 98.1% of the fluid flowing through the drainage lumen enters the lumen through the two closest openings. Compared to Example 1, Example 2 increases the flow through the proximal end of the tube. Thus, Example 1 provides a wider flow distribution in which a greater percentage of fluid enters the drainage lumen through openings other than the nearest opening. In this way, fluid can be more efficiently collected through the multiple openings, thereby reducing fluid backflow and improving negative pressure distribution over the renal pelvis and / or kidney.

[0362] Table 4:

[0363] Location Traffic Distribution % diameter (mm) Length (mm) Cu...

Embodiment 3

[0365] Example 2 also shows the flow distribution for equal diameter openings. However, as shown in Table 5, the spacing of these openings is smaller (10 mm compared to 22 mm). as table 5 and Figure 15B As shown, 80.9% of the fluid flowing through the drainage lumen is through the nearest opening (Q 6 ) into the drainage lumen. 96.3% of the fluid in the drainage lumen is through the two closest openings (Q 5 and Q 6 ) into the drainage lumen.

[0366] table 5:

[0367] Location Traffic Distribution % diameter (mm) Length (mm) Cumulative length (mm) Q 6 '(close)

80.9％ 0.88 0 0 Q 5 ’

15.4％ 0.88 10 10 Q 4 ’

2.9％ 0.88 10 20 Q 3 ’

0.6％ 0.88 10 30 Q 2 ’

0.1％ 0.88 10 40 Q 1 '(Far)

0.02％ 0.97 15 55 Q 总

100％

[0368] see now in general Figure 17-41C , see more specifically Figure 17 , which shows a bladder catheter 116 and two exemplary ureteral catheters 5000, 5001 deployed i...

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Abstract

A coated and / or impregnated urinary catheter or urinary stent device includes: (a) a proximal portion, and (b) a distal portion. The distal portion comprises: a retention portion that includes at least one protected drainage hole(s), port(s) or perforation(s) and is configured to establish an outer periphery or protective surface area that inhibits mucosal tissue from occluding the at least one protected drainage hole(s), port(s) or perforation(s) upon application of negative pressure through the catheter; and at least one coating(s) upon and / or at least one impregnation(s) within at least a portion of the protective surface area, the at least one coating(s) and / or at least one impregnation(s) including at least one of lubricant(s), antimicrobial material(s), pH buffer(s) or anti-inflammatory material(s).

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Patent Application No. 16 / 696,026, filed November 26, 2019, which is U.S. Patent Application No. 16 / 206,389, filed November 30, 2018 A continuation-in-part of U.S. Patent Application No. 16 / 206,389, which is a continuation-in-part of U.S. Patent Application No. 15 / 879,770, filed January 25, 2018, and U.S. Patent Application No. 15 / 879,770, filed August 2017 Continuation-in-Part of U.S. Patent Application No. 15 / 687,064, filed on January 25, U.S. Patent Application No. 15 / 687,064 is a continuation-in-part of U.S. Patent Application No. 15 / 411,884, filed January 20, 2017, No. 15 U.S. Patent Application No. 411,884 is a continuation-in-part of U.S. Patent Application No. 15 / 214,955 filed on July 20, 2016, which claims 62 / U.S. Provisional Application No. 300,025, U.S. Provisional Application No. 62 / 278,721 filed January 14, 2016, U.S. Provisional Application No. 62 / 260,966 filed Nove...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L29/16
CPCA61L29/16A61L2300/41A61L2300/404A61L2400/10A61L29/14A61L2420/08A61L29/085A61M25/04A61M25/007A61M27/008
Inventor 约翰·R·厄尔贝二世布莱恩·J·塔克雅各布·L·厄珀可
Owner ROIVIOS LIMITED
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