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Circulating spon-1 (spondin-1) in the assessment of atrial fibrillation

A technology of SPON-1 and atrial fibrillation, applied in the direction of anti-animal/human immunoglobulin, instruments, analytical materials, etc., can solve the problem that the risk of atrial fibrillation is not significantly related

Pending Publication Date: 2021-08-24
F HOFFMANN LA ROCHE & CO AG +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

SPON-1 demonstrated no significant association with atrial fibrillation risk

Method used

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  • Circulating spon-1 (spondin-1) in the assessment of atrial fibrillation
  • Circulating spon-1 (spondin-1) in the assessment of atrial fibrillation
  • Circulating spon-1 (spondin-1) in the assessment of atrial fibrillation

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0321] Example 1: Assessing AF with Loop SPON-1

[0322] The MAPPING study involved patients undergoing thoracotomy. Samples were obtained prior to anesthesia and surgery. Patients were electrophysiologically characterized using high-density epicardial mapping (high-density mapping) with a multielectrode array.

[0323] Circulating SPON-1 levels have been determined in 16 patients with persistent atrial fibrillation and 30 controls for optimal (age, sex, comorbidities) matching. SPON-1 was determined in samples from the MAPPING study.

[0324] Measurements were performed in 30 patients with sinus rhythm (SR) and 16 patients with persistent atrial fibrillation (persAF).

[0325] figure 1 SPON-1 was shown to be significantly elevated in persAF patients compared to SR patients (AUC 0.87). figure 1 The boxplots in show the distribution of SPON-1 in SR patients versus persAF patients. ROC curves showing the diagnostic ability of SPON-1 to distinguish SR patients from persAF p...

example 2

[0327] Example 2: Prediction of stroke

[0328] Analytical method

[0329] The ability of circulating SPON-1 to predict the risk of stroke was assessed in a prospective multicenter registry of patients with documented atrial fibrillation (Conen D., Forum Med Suisse 2012; 12:860-862). SPON-1 was measured using a stratified case cohort design as described by Borgan (2000).

[0330] For each of the 70 patients who experienced a stroke ("event") during the follow-up period, 1 matched control was selected. Controls were matched on the basis of demographic and clinical information on age, sex, history of hypertension, type of atrial fibrillation, and history of heart failure (CHF history).

[0331] SPON-1 results were available for 67 patients with events and 66 patients without events.

[0332] SPON-1 was measured using the Olink platform, therefore no absolute concentration values ​​are available and reportable. Results will be reported in arbitrary signal scale (NPX).

[0333]...

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Abstract

The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of SPON-1 in a sample from the subject, and comparing the amount of SPON-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for the prediction of stroke based on the amount of SPON-1.

Description

technical field [0001] The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of: determining the amount of SPON-1 in a sample from the subject, and comparing the amount of SPON-1 with a reference amount , to assess atrial fibrillation. Furthermore, the present invention relates to methods for predicting stroke based on the amount of SPON-1. Background technique [0002] Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and one of the most prevalent conditions in the elderly population. Atrial fibrillation is characterized by irregular heart beats and usually begins with a brief abnormal beat that increases over time and can become a permanent condition. An estimated 2.7-6.1 million Americans have atrial fibrillation, and approximately 33 million people worldwide have atrial fibrillation (Chugh S.S. et al., Circulation 2014; 129:837-47). [0003] Diagnosis of cardiac arrhythmias, such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/2871G01N2800/326G01N2333/58G01N2800/50G16B25/10C07K16/18G01N2333/515
Inventor P·卡斯特纳M·迪特里希A·齐格勒U-H·维恩胡斯-特伦V·罗尼U·肖滕
Owner F HOFFMANN LA ROCHE & CO AG
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