Fluvoxamine clinical precise application virtual simulation experiment system based on CYP2D6 genotype

A technology of fluvoxamine and virtual simulation, applied in the field of virtual simulation experiment system, can solve problems such as difficulty in meeting class hours, scarcity of teachers, and high difficulty in teaching

Pending Publication Date: 2021-08-17
WENZHOU MEDICAL UNIV
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Problems solved by technology

[0004] Fluvoxamine precision drug use involves a wide range of knowledge, including clinical medicine, genetics, molecular biology, pharmacology, etc. Considering that actual teaching cannot directly target patients for research, laboratory development of genetic testing and a complete set of clinical pharmacy services It is difficult to meet the class hours required for teaching, and there are a series of problems such as the scarcity of teachers who have the knowledge system to implement precision medicine. It is difficult to implement integrated teaching offline for this project

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  • Fluvoxamine clinical precise application virtual simulation experiment system based on CYP2D6 genotype
  • Fluvoxamine clinical precise application virtual simulation experiment system based on CYP2D6 genotype
  • Fluvoxamine clinical precise application virtual simulation experiment system based on CYP2D6 genotype

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[0027] The principles and characteristics of the present invention are described below in conjunction with the accompanying drawings, which are only used to explain the present invention rather than limit the content of the present invention.

[0028] Such as figure 1 As shown, the present invention combines online virtual simulation with offline experimental operations. Taking clinical cases as the background, patients with severe liver damage after taking fluvoxamine derive the problem of how to adjust the dosage of adverse reactions. From the perspective of pharmacokinetics From a scientific point of view, students are guided to discover the main metabolic enzyme CYP2D6 of the drug, and then conduct blood collection, DNA extraction, PCR, sequencing and other steps through online virtual experiments. Analyze the case and give a solution. In the process of online operation, practice questions are set up to conduct tests to test the learning effect and provide reference for o...

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Abstract

The invention discloses a fluvoxamine clinical precise application virtual simulation experiment platform based on a CYP2D6 genotype, the platform is oriented to clinical problems, a complete knowledge system of laboratory research and pharmaceutical service is built, students' understanding of precise medication is cultivated, and specifically, according to the project, students are guided to understand and master gene sequencing and analysis according to the ideas of drug monitoring, drug enzyme gene detection, metabolic type judgment, guide searching and individualized drug administration scheme making of special crowds.

Description

technical field [0001] The invention belongs to the field of medical education, and specifically relates to a virtual simulation experiment system for precise clinical application of a compound of formula (I) (fluvoxamine) based on CYP2D6 genotype. [0002] Background technique [0003] Cytochrome P450 (CYP) is an important enzyme system for the human body to metabolize exogenous substances (such as drugs, poisons, etc.), mainly catalyzing the oxidation reaction of substrates. Among them, CYP2D6 only accounts for 2% of liver microsomes, but participates in the metabolism of 20% of clinical drugs, and is the main metabolic enzyme of fluvoxamine. However, due to the existence of gene polymorphisms in CYP2D6, there are significant differences in activity, and there are also differences in the metabolism of fluvoxamine, which will cause differences in the efficacy of clinical drugs. Therefore, it is of great clinical significance to detect the patient's genotype and, accordi...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/20G16H70/40G06F30/20
CPCG16B20/20G16H70/40G06F30/20
Inventor 钱建畅胡国新蔡剑平陈冰冰高楠勇
Owner WENZHOU MEDICAL UNIV
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