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Extraction method of 2-(2-phenethyl) chromone components in agalloch eaglewood and application of 2-(2-phenethyl) chromone components

A kind of technology of Qinan agarwood and extraction method, which is applied in the field of extraction of 2-chromone components in Qinan agarwood, and can solve the problems of side effects, insignificant effect, easy recurrence and the like.

Active Publication Date: 2021-08-17
INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Beauty is the innate pursuit of people, especially women, but the current whitening skin care products on the market mainly use chemical sunscreens, depigmentation or exfoliation of cuticles, the effect is not obvious and easy to relapse, and there are certain side effects. Difficulties have always plagued people who love beauty

Method used

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  • Extraction method of 2-(2-phenethyl) chromone components in agalloch eaglewood and application of 2-(2-phenethyl) chromone components
  • Extraction method of 2-(2-phenethyl) chromone components in agalloch eaglewood and application of 2-(2-phenethyl) chromone components
  • Extraction method of 2-(2-phenethyl) chromone components in agalloch eaglewood and application of 2-(2-phenethyl) chromone components

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Experimental program
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Effect test

Embodiment 1

[0034] The rapid preparation of two 2-(2-phenylethyl) chromones of embodiment 1

[0035] Take 100g of dried Agarwood chinensis, put it into a flash extractor after crushing, add 5 times of 75% ethanol, stir at a high speed (6000 times / min) at room temperature to break the cell tissue wall, extract for 1min, and then After putting it into a cold storage at 4° C. for 12 hours, filter to obtain the supernatant. Concentrate by flash evaporation at 45°C to obtain agarwood extract. The agarwood extract was separated at a vacuum degree of 300mTorr, a heating temperature of 80°C, a sample injection speed of 3s / drop, and a cooling temperature of 10°C, and the heavy components were collected. The heavy component mixture was separated by Sephadex LH-20 column chromatography, methanol-water (volume ratio 7:3), eluted at a flow rate of 1.5mL / min to obtain 8.4 grams of 2-(2-phenylethyl)chromone, 2 10.2 grams of [2-(4-methoxy)phenethyl]chromone, with a purity of over 93%.

Embodiment 2

[0036] The rapid preparation of two 2-(2-phenylethyl) chromones of embodiment 2

[0037] Take 100g of dried Agarwood chinensis, put it into a flash extractor after crushing, add 8 times of 85% ethanol, stir at a high speed (7500 times / min) at room temperature to break the cell tissue wall, extract for 2min, and then After putting it into a cold storage at 2° C. for 12 h, filter to obtain the supernatant. Concentrate by flash evaporation at 50°C to obtain agarwood extract. The agarwood extract was separated at a vacuum degree of 200mTorr, a heating temperature of 70°C, a sample injection speed of 2s / drop, and a cooling temperature of 8°C, and the heavy components were collected. The heavy component mixture was separated by Sephadex LH-20 column chromatography, methanol-water (volume ratio 8:2), eluted at a flow rate of 1.5mL / min to obtain 9.8 grams of 2-(2-phenylethyl)chromone, 2 11.9 grams of [2-(4-methoxy)phenethyl]chromone, with a purity of over 95%.

Embodiment 3

[0038] The rapid preparation of two 2-(2-phenylethyl) chromones of embodiment 3

[0039]Take 100g of dried Agarwood chinensis, put it into a flash extractor after crushing, add 10 times of 95% ethanol, stir at a high speed (9000 times / min) at room temperature to break the cell tissue wall, extract for 3 minutes, and then After putting it into a cold storage at 0° C. for 12 h, filter to obtain the supernatant. Concentrate by flash evaporation at 55°C to obtain agarwood extract. The agarwood extract was separated at a vacuum degree of 100mTorr, a heating temperature of 60°C, an injection speed of 1s / drop, and a cooling temperature of 5°C, and the heavy components were collected. The heavy component mixture was separated by Sephadex LH-20 column chromatography, methanol-water (volume ratio 10:1), eluted at a flow rate of 1.5mL / min to obtain 11.2 grams of 2-(2-phenylethyl)chromone, 2 13.6 grams of [2-(4-methoxy)phenethyl]chromone, with a purity of over 98%.

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Abstract

The invention provides an extraction method and application of 2-(2-phenethyl) chromone components in agalloch eaglewood and application of the 2-(2-phenethyl) chromone components. The extraction method comprises the following steps: drying the agalloch eaglewood, crushing, performing ethanol extraction by using a flash method, and performing flash evaporation concentration to obtain a concentrated solution; carrying out molecular distillation on the concentrated solution to obtain a heavy component; and separating the heavy component by dextran gel chromatography to obtain a 2-(2-phenylethyl) chromone component; The 2-(2-phenethyl) chromone components mainly comprise 2-(2-phenethyl) chromone and 2-[2-(4-methoxy) phenethyl] chromone. The extraction method provided by the invention is simple, convenient and rapid, and the extracted 2-(2-phenethyl) chromone and 2-[2-(4-methoxy) phenethyl] chromone are high in purity, can effectively inhibit the activity of tyrosinase, and have a good application prospect in the aspects of whitening and removing freckles.

Description

technical field [0001] The invention belongs to the technical field of medicine and daily chemical products, and in particular relates to a method for extracting 2-(2-phenylethyl)chromone components in Agarwood chinensis and its application. Background technique [0002] Agarwood is the wood of Aquilaria Lam. or Gyrinops Gaertn. in the family Thymelaeaceae that contains black resin. Because of its wide application value in medicine, aromatherapy, perfume industry, religious culture and other fields, especially because of its special and pleasant aroma, it has become a traditional precious medicinal material and medicinal material in my country, Japan, India and other Southeast Asian countries. Natural flavors. It has the effects of promoting qi and relieving pain, warming middle-JIAO and relieving vomiting, inducing qi and relieving asthma. It is recorded in the ancient medical book "Puji Fang" that agarwood has the beauty effects of promoting blood circulation and beautify...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/40C07D311/22A61K8/49A61Q19/02A61K31/352A61P17/00
CPCC07D311/40C07D311/22A61K8/498A61Q19/02A61K31/352A61P17/00A61K2800/782Y02A50/30
Inventor 董文化梅文莉王雅丽杨理王昊李薇戴好富
Owner INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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