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Multi-layer composite embolism microsphere

A multi-layer composite, microsphere technology, applied in the field of medicine, can solve the problems of inability to sequentially release multiple drugs, long degradation period, fast drug release speed, etc., to achieve drug synergy, reduce toxic side effects, and prolong sustained release. effect of time

Active Publication Date: 2021-08-10
谢辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the shortcomings of the prior art such as single drug loading, inability to sequentially release multiple drugs, fast drug release speed, and long degradation cycle, the present invention adopts microsphere composite sustained release technology, multi-layer microsphere composite technology, and supplemented with sodium alginate Preparation of a Multilayer Double Composite Microsphere by Modification Technology

Method used

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  • Multi-layer composite embolism microsphere
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  • Multi-layer composite embolism microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Preparation of PLGA microspheres

[0033] 1) Take 1 g of PLGA (55 / 45) with a viscosity of 0.35 dl / g, dissolve it in 33 ml of tetrahydrofuran to prepare a tetrahydrofuran solution of PLGA with a mass volume fraction of 3%;

[0034] 2) Weigh 0.05g of cisplatin, add cisplatin into 5ml of dimethylformamide and stir evenly, and prepare a solution with a mass volume fraction of 1%;

[0035]3) Place the PLGA solution in the outer tube sampling device of the coaxial sleeve of the electrostatic droplet equipment, place the cisplatin solution in the inner tube sampling device of the coaxial sleeve of the electrostatic droplet equipment, and set the molding voltage to 30kv , the inner diameter of the inner nozzle of the coaxial casing is 0.06mm, the inner diameter of the outer nozzle is 0.2mm, the injection speed is adjusted to 0.2mL / h, the annular coil is placed at 2cm below the nozzle, and ethanol-water (volume ratio 9:1 ) receiver is placed 10cm directly below the nozzle t...

Embodiment 2

[0044] (1) Preparation of PLGA microspheres

[0045] 1) Take 1g of PLGA (50 / 50) with a viscosity of 0.35dl / g and dissolve it in 20ml of dichloromethane to prepare a 5% PLGA solution in dichloromethane;

[0046] 2) Weigh 0.1g of cisplatin, add cisplatin into 10ml of dimethylformamide and stir evenly, and prepare a solution with a mass volume fraction of 1%;

[0047] 3) Place the PLGA solution in the outer tube sampling device of the coaxial sleeve of the electrostatic droplet equipment, place the cisplatin solution in the inner tube sampling device of the coaxial sleeve of the electrostatic droplet equipment, and set the molding voltage to 25kv , the inner diameter of the inner nozzle of the coaxial sleeve is 0.06mm, the inner diameter of the outer nozzle is 0.2mm, the injection speed is adjusted to 2mL / h, the annular coil is placed 2cm below the nozzle, and ethanol-water (volume ratio 9:1) The receiver is placed 10cm directly below the nozzle to collect the microspheres, and ...

Embodiment 3

[0056] (1) Preparation of PLGA microspheres

[0057] 1) Take 2g of PLGA (55 / 45) with a viscosity of 0.1dl / g and dissolve it in 40ml of tetrahydrofuran to prepare a tetrahydrofuran solution of PLGA with a mass volume fraction of 5%;

[0058] 2) Weigh 0.2g of cisplatin, add cisplatin into 10ml of dimethylformamide and stir evenly, and prepare a solution with a mass volume fraction of 2%;

[0059] 3) Place the PLGA solution in the outer tube sampling device of the coaxial sleeve of the electrostatic droplet equipment, place the cisplatin solution in the inner tube sampling device of the coaxial sleeve of the electrostatic droplet equipment, and set the molding voltage to 10kv , the inner diameter of the inner nozzle of the coaxial sleeve is 0.06mm, the inner diameter of the outer nozzle is 0.2mm, the injection speed is adjusted to 2mL / h, the annular coil is placed 2cm below the nozzle, and ethanol-water (volume ratio 9:1) The receiver is placed 10cm directly below the nozzle to ...

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Abstract

The invention relates to a multi-layer composite embolism microsphere which consists of a plurality of layers of microspheres. The multi-layer composite embolism microsphere is sequentially composed of a PLGA core-shell drug-loaded microsphere, a modified sodium alginate microsphere wrapping the PLGA core-shell drug-loaded microsphere, a carboxymethyl chitosan microsphere wrapping a modified sodium alginate layer and a sodium alginate layer wrapping the carboxymethyl chitosan microsphere from inside to outside. Through multi-layer drug loading and modification design of sodium alginate, the prepared microspheres not only can stably and uniformly release drugs for a long time and realize effective chemotherapy in the whole embolism period, but also can load different drugs to realize sequential release of the drugs, reduce toxic and side effects and realize synergistic effect of the drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a multilayer composite embolic microsphere. Through multi-layer drug loading and modified design of sodium alginate, the prepared microspheres can not only release drugs stably and uniformly for a long time, realize effective chemotherapy in the whole embolization cycle, but also can load different drugs to realize drug release in sequence, reducing toxicity side effects and achieve drug synergy. Background technique [0002] Tumor interventional therapy is one of the main methods of malignant tumor treatment, and it is also the main means of non-surgical treatment of tumors. Interventional therapy combines medical imaging and clinical treatment and other disciplines technically. It is simple, safe, minimally invasive, and has few complications after treatment. It has become one of the most important technologies for tumor interventional therapy. [0003] Compared with irregular ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/34A61K47/36A61K45/00A61P35/00
CPCA61K9/5073A61K9/5036A61K9/5031A61K45/00A61P35/00A61K9/5089
Inventor 谢辉王君箫王华明田圣涛
Owner 谢辉
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