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Multi-cavity microsphere with gradient structure and preparation method

A gradient structure and multi-chamber technology, which is applied in the fields of biology and chemical technology, can solve the problems of limited size and load capacity, and the inability to effectively control the number of chambers. promising effect

Active Publication Date: 2021-07-30
SOUTHWEST JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of the above-mentioned deficiencies or defects, the purpose of the present invention is to provide a multi-chamber microsphere with a gradient structure and a preparation method, which can effectively solve the problem that the number, size and load of the chambers cannot be effectively controlled in the existing multi-chamber structure. The problem of limited capacity

Method used

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  • Multi-cavity microsphere with gradient structure and preparation method

Examples

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Embodiment 1

[0030] A method for preparing a magnetic adsorption inner chamber and a gradient multi-chamber coated with crystalline macromolecules, the specific steps are as follows:

[0031] (1) Use a sucrose molecule with a relative molecular mass of 3000-5000 and 4-6 moles of hydroxyl per mole and a molecular weight of 5000-10000 with -CH per mole 2 -Polycaprolactone molecules with a mass ratio of 70-80% are synthesized to obtain amphiphilic block copolymers with a molecular weight of 8000-15000; and then self-assembled to obtain spherical micelles;

[0032] (2) Then spherical micelles and citric acid-modified ferroferric oxide magnetic nanoparticles are added into a volatile solvent in a molar ratio of 1:2, specifically tetrahydrofuran, mixed evenly, dropped into distilled water, and stirred until uniform Mix; mechanically stir at a constant speed of 80rpm under a 40°C water bath, add a certain amount of acetic acid solution to adjust the pH value to 4.0 after 2 hours, and adjust the s...

Embodiment 2

[0035] The difference between this example and Example 1 is only that a certain amount of acetic acid solution is added to adjust the pH value to 5.0, and the metastable polymer formed by magnetic attraction has an average of 3 chambers.

Embodiment 3

[0037] The difference between this example and Example 1 is only: adding a certain amount of acid solution to adjust the pH value is dilute hydrochloric acid, the adjusted pH value is 4.0, and the metastable polymer formed by magnetic attraction has an average of 6 cavities chamber with an average particle size of 650 nm. The TEM image of its structural characterization is shown in figure 2 .

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Abstract

The invention discloses a multi-cavity microsphere with a gradient structure and a preparation method thereof, and mainly relates to the following steps: connecting an amphiphilic block copolymer and hydrophilic modified magnetic nanoparticles according to a certain proportion, and self-assembling the amphiphilic block copolymer and the hydrophilic modified magnetic nanoparticles into an aggregate with a magnetic adsorption connected spherical micelle inner cavity structure under the combined action of a solvent and magnetism; and further coating the multi-cavity aggregate by using crystalline hydrophilic molecules to form the stable multi-cavity microsphere with a gradient structure. The multi-cavity system disclosed by the invention has the characteristics of controllable structure size and controllable cavity number, and can be filled with different functional molecules, so that a carrier function with multiple functional drugs / development can be realized, and a new structure is developed for the field of nano diagnosis and treatment integration.

Description

technical field [0001] The invention relates to the fields of biology and chemical technology, in particular to a multi-chamber microsphere with a gradient structure and a preparation method. Background technique [0002] Block copolymers are block copolymers that have two or more segments with different structures in a single linear copolymer molecule, and amphiphilic block copolymers that contain both a hydrophilic part and a hydrophobic part. A class of polymers, which can self-assemble into a stable, structurally controllable micellar system through non-covalent bonds. The self-assembly behavior of micelles has always been a hot research direction. Controlling the environmental conditions for the formation of micelles The critical micelle concentration can be changed. The micelle has an internal hydrophobic cavity and the particle size is smaller than liposomes and polymer microspheres. It has broad application prospects in the fields of drug controlled release, biomedic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/10
CPCB01J13/10
Inventor 郑晓彤孔德港郑志文吴卓尧方博洋张依懿干智杰王鉴文何静
Owner SOUTHWEST JIAOTONG UNIV
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