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A kind of multi-chamber microsphere with gradient structure and preparation method thereof

A gradient structure and multi-chamber technology, which is applied in the fields of biology and chemical technology, can solve the problems of limited size and load capacity, and the inability to effectively control the number of chambers, so as to achieve simple and feasible preparation methods, distinctive characteristics of prepared products, and product application promising effect

Active Publication Date: 2022-07-15
SOUTHWEST JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] In view of the above-mentioned deficiencies or defects, the purpose of the present invention is to provide a multi-chamber microsphere with a gradient structure and a preparation method, which can effectively solve the problem that the number, size and load of the chambers cannot be effectively controlled in the existing multi-chamber structure. The problem of limited capacity

Method used

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  • A kind of multi-chamber microsphere with gradient structure and preparation method thereof
  • A kind of multi-chamber microsphere with gradient structure and preparation method thereof

Examples

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Embodiment 1

[0030] A method for preparing a magnetic adsorption inner chamber and a gradient multi-chamber coated with crystalline macromolecules, the specific steps are as follows:

[0031] (1) Use a sucrose molecule with a relative molecular mass of 3000-5000, containing 4-6 moles of hydroxyl groups per mole molecule and a molecular weight of 5000-10000, containing -CH per mole molecule 2 - Polycaprolactone molecules with a mass ratio of 70-80% are synthesized to obtain an amphiphilic block copolymer with a molecular weight of 8000-15000; and then self-assembled to obtain spherical micelles;

[0032] (2) adding spherical micelles and citric acid-modified ferroferric oxide magnetic nanoparticles in a molar ratio of 1:2, adding a volatile solvent, specifically tetrahydrofuran, mixing uniformly and then dropping into distilled water, stirring until uniform Mix; mechanically stir at a constant speed of 80 rpm under a 40°C water bath, add a certain amount of acetic acid solution to adjust th...

Embodiment 2

[0035] The difference between this example and Example 1 is only that a certain amount of acetic acid solution is added to adjust the pH value to 5.0, and the metastable polymer formed by magnetic attraction has an average of 3 chambers.

Embodiment 3

[0037] The difference between this example and Example 1 is only: adding a certain amount of acid solution to regulate pH value is dilute hydrochloric acid, the pH value of regulation is 4.0, and the metastable polymer formed by magnetic attraction has an average of 6 cavities chambers with an average particle size of 650 nm. The TEM image of its structural characterization is shown in figure 2 .

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Abstract

The invention discloses a multi-chamber microsphere with a gradient structure and a preparation method, which mainly involve: using an amphiphilic block copolymer and hydrophilic modified magnetic nanoparticles to connect in a certain proportion; The multi-chamber aggregates are further coated with crystalline hydrophilic molecules to form stable multi-chamber micro-organisms with gradient structure. ball. The multi-chamber system of the present invention has the characteristics of controllable structure size and number of chambers, and the multi-chamber system can be filled with different functional molecules, so as to realize the carrier function with multiple functional drugs / imaging, which is a nano-diagnosis and treatment A new structure has been developed in the field of integration.

Description

technical field [0001] The invention relates to the field of biology and chemical technology, in particular to a multi-chamber microsphere with a gradient structure and a preparation method. Background technique [0002] A block copolymer is a block copolymer, which means that there are two or more segments with different structures in a single linear copolymer molecule, and an amphiphilic block copolymer that contains both a hydrophilic part and a hydrophobic part. A class of polymers that can self-assemble into a stable and structurally controllable micellar system through the action of non-covalent bonds. The self-assembly behavior of micelles has always been a hot research direction. Controlling the environmental conditions for the formation of micelles Its critical micelle concentration can be changed. The micelle has an internal hydrophobic cavity and a smaller particle size than liposomes and polymer microspheres. It has broad application prospects in the fields of dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/10
CPCB01J13/10
Inventor 郑晓彤孔德港郑志文吴卓尧方博洋张依懿干智杰王鉴文何静
Owner SOUTHWEST JIAOTONG UNIV
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