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Composition with function of enhancing phagocytic activity of macrophages, application thereof, and immune medicine

A technology of macrophages and compositions, applied in the field of medicine, can solve problems such as limitations

Active Publication Date: 2021-07-30
国珍健康科技(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current stimulating substances are relatively limited, and the effect of enhancing the phagocytic ability of macrophages is given priority. It is necessary to find other substances that can improve the phagocytic activity of macrophages

Method used

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  • Composition with function of enhancing phagocytic activity of macrophages, application thereof, and immune medicine
  • Composition with function of enhancing phagocytic activity of macrophages, application thereof, and immune medicine
  • Composition with function of enhancing phagocytic activity of macrophages, application thereof, and immune medicine

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preparation example Construction

[0051] In a preferred embodiment, the preparation method of the pine flower aqueous extract comprises the steps:

[0052] The preparation method of described pine flower aqueous extract comprises the steps:

[0053] mixing pine pollen with water, and ultrasonically preparing the pine flower water extract under heating conditions;

[0054] Preferably, the mass ratio of the pine pollen to water is 1:(8-12), for example, but not limited to 1:8, 1:9, 1:10, 1:11 or 1:12, preferably 1:10;

[0055] Preferably, the heating temperature is 25-45°C, for example, but not limited to 25°C, 30°C, 35°C, 40°C or 45°C, preferably 37°C;

[0056] Preferably, the ultrasonic time is 10-30 minutes, for example, but not limited to 10 minutes, 15 minutes, 20 minutes, 25 minutes or 30 minutes, preferably 20 minutes.

[0057] In the present invention, by further optimizing and adjusting the preparation method of the pine flower water extract, the extraction of effective substances in the pine pollen is...

Embodiment 1

[0078] 1. Raw material preparation

[0079] (1) Fucoidan: Take 200mg of fucoidan in 2ml of hot water, ultrasonically dissolve it for 10 minutes, pass through a 0.22μm filter membrane to make a 100mg / ml stock solution of fucoidan, and store it in a refrigerator at 5°C for later use.

[0080] (2) Elderberry: Weida International Co., Ltd., containing 10% anthocyanins, prepared 40mg / ml elderberry stock, dissolved 200mg extract in 5ml water, sterilized through a 0.22μm filter membrane, -20℃ Store for later use.

[0081] (3) Pterostilbene: Take 200mg of pterostilbene in 2ml of 50% ethanol, fully pipette and dissolve, pass through a 0.22μm filter membrane to prepare a 100mg / ml pterostilbene stock solution, and store it in a refrigerator at 5°C for later use.

[0082] (4) Songhua water extract: Take 500mg of pine pollen in 5ml of water, bathe at 37°C, ultrasonicate for 20min, pass through a 0.22μm filter membrane to make 100mg / ml Songhua water extract stock solution, put it in a refr...

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Abstract

The invention provides a composition with a function of enhancing phagocytic activity of macrophages, application thereof, and an immune medicine, and relates to the technical field of medicines. The composition with the function of enhancing the phagocytic activity of the macrophages, provided by the invention, comprises fucoidan and elderberry, and the inventor finds that the fucoidan and the elderberry both have an immunoregulation function and can enhance the phagocytic activity of the macrophages and inhibit lipopolysaccharide from inducing the macrophages to secrete nitric oxide, the effect of enhancing the phagocytic activity of the macrophages by jointly using the fucoidan and the elderberry is obviously better than that of a single component, the fucoidan and the elderberry have a synergistic effect, and the fucoidan and the elderberry are safe and reliable and can be used for preparing the medicine for enhancing the phagocytic activity of the macrophages.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition capable of enhancing the phagocytic activity of macrophages, its application and immune medicine. Background technique [0002] Macrophages (Macrophages) are white blood cells located in tissues, derived from monocytes, and play an important role in body development, immunity, inflammatory response and the occurrence of various diseases by phagocytizing autologous damaged cells or foreign pathogens. That said, they are involved in nearly every human disease and they are also major therapeutic targets because their function can be enhanced or inhibited to alter disease outcome. Therefore, improving the phagocytic activity of macrophages is helpful to the improvement of the body's immune level and the treatment of various diseases. [0003] Existing studies have shown that macrophages in living organisms can change their phenotype and immune function with changes in...

Claims

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Application Information

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IPC IPC(8): A61K36/35A61K31/715A61K36/15A61K39/39A61K39/00A61P37/04
CPCA61K36/35A61K31/715A61K36/15A61K39/39A61K39/00A61P37/04A61K2039/55588A61K2039/55583A61K2039/55511A61K2039/572A61K2300/00
Inventor 张薛勤邢岩张丽梅李永强李爱民李颖
Owner 国珍健康科技(北京)有限公司
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