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TCR-enriched clonotype as well as acquisition method and application thereof

A kind of acquisition method, clonotype technology, applied in the field of TCR enrichment clonotype and its acquisition

Inactive Publication Date: 2021-07-23
HUNAN YUANPIN CELL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Most of them use the same method as SARS in the past for symptomatic treatment, using hormones to suppress the inflammatory response triggered by the immune system, but at the same time, it will also make people feel very fragile and will inevitably be damaged

Method used

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  • TCR-enriched clonotype as well as acquisition method and application thereof
  • TCR-enriched clonotype as well as acquisition method and application thereof
  • TCR-enriched clonotype as well as acquisition method and application thereof

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Embodiment Construction

[0020] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0021] The present invention provides a TCR enriched clonotype, the amino acid sequence of the TCR enriched clonotype is: CAASAVGGAQKLVF_CATSRGTLYGYTF.

[0022] Wherein, the TCR-enriched clonotype is enriched in cell clusters of effector CD4+T memory cells.

[0023] Such as figure 1 As shown, the present invention also provides a method for obtaining the above-mentioned TCR-enriched clonotype, comprising the following steps:

[0024] S1. Collection of peripheral blood mononuclear cell samples from cured patients with viral infection;

[0025] S2. Perform TCR / BCR V(D)J immune repertoire sequencing analysis on the collected samples to find the common CDR3 variable region;

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Abstract

The invention relates to the technical field of biological medicine, and particularly discloses a TCR-enriched clonotype as well as an acquisition method and application thereof. The amino acid sequence of the TCR-enriched clonotype is CAASAVGGAQKLVF_CATSRGTLYGYTF, and the TCR-enriched clonotype can provide specifically recognized epitopes for vaccine development, so that the TCR-enriched clonotype can be used for guiding vaccine development and providing direction and theoretical basis for vaccine development and research.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a TCR-enriched clonotype and its acquisition method and application. Background technique [0002] The outbreak of novel coronavirus (2019-novel coronavirus, 2019-nCoV) infection poses a serious threat to global public health. The disease caused by 2019-nCoV was officially named COVID-19 (coronavirus disease 2019) by the World Health Organization (WHO). COVID-19 is clinically manifested as pneumonia, fever, cough, muscle pain, fatigue, diarrhea and, in severe cases, death. The WHO report shows that 2019-nCoV has caused a worldwide pandemic. Vaccination is an effective means to prevent the spread of viral infection, but there is currently no new coronavirus vaccine (hereinafter referred to as the new crown vaccine). For the rapid spread of the COVID-19 virus in the public, the current treatment is still based on supportive care. Antiviral drugs, antibodies, and vaccines aga...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/725C12N5/0783
CPCC07K14/7051C12N5/0636C12N2509/00
Inventor 齐凌彬薛志刚薛金锋李婵艺吕波伊宁李伟林
Owner HUNAN YUANPIN CELL TECH CO LTD
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