A gene detection kit for individualized medication of antiepileptic drugs and its application

Abstract

The invention belongs to the field of gene detection, and in particular relates to a gene detection kit for individualized antiepileptic drug administration and its application. The kit provided by the present invention mainly includes library primer mixture, multiplex PCR library amplification buffer, digestion buffer, ligation buffer, ligase, specific linker, HiFi library amplification buffer, positive / negative quality control, Reporting system, instructions. The kit provided by the invention can be used to detect 10 commonly used anti-epileptic clinical drugs, with a total of 44 genes and 103 detection sites; it realizes the related gene detection and report analysis for the prediction of the curative effect and adverse reactions of anti-epileptic drugs. medication assistance.

Description

technical field [0001] The invention belongs to the field of gene detection, and in particular relates to a gene detection kit for individualized medication of antiepileptic drugs and its application. Background technique [0002] Epilepsy is a chronic disease caused by abnormal and excessive hypersynchronized discharge of brain neurons, and its clinical manifestations are motor, sensory, consciousness and autonomic nervous system disorders. According to the World Health Organization (WHO) data, there are currently about 50 million people with epilepsy in the world, of which about 80% are in developing countries, and the prevalence of epilepsy is about 7.2‰; the prevalence of epilepsy in my country is 4‰~8‰, At present, there are about 10 million epilepsy patients in China. Epilepsy, as a neurological disease with a high incidence, is a major killer of human health after cardiovascular and cerebrovascular diseases. [0003] At present, the treatment methods for epilepsy mai...

AI Technical Summary

Problems solved by technology

In order to solve the problem that the existing detection products cover few drugs and genes, and the prediction is not accurate enough, new and effective treatment options are needed for patients; drugs involve many related genes and sites, and the interpretation is complicated, which is not conducive to clinicians' interpretation or utilization The market needs an efficient and convenient antiepileptic drug gene detection kit to improve the accuracy of antiepileptic drug use and reduce the probability of adverse drug reactions. Based on this, the present invention provides an antiepileptic drug. Gene detection kit and its application for individualized medication of epilepsy drugs

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